ReviewNeuroscience and biobehavioral reviews2016
Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals.
Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- Appetitive startle modulation in the human laboratory predicts Cannabis craving in the natural environment.Psychopharmacology · 2018Trial
- The serial effect of bullying victimization and aggression outcome expectancies on within-person changes in proactive aggression among adolescents across one year.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Article
- Pediatric Headache in the Age of Social Media: A Topical Review.Current pain and headache reports · 2026Review
- More than just a phase: adolescence as a window into how the brain generates behavior.Current directions in psychological science · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- The CB1 receptor: linking impulsivity and substance use disorder.Frontiers in neuroscience · 2025Review
- Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain.Frontiers in molecular neuroscience · 2025Article
- Sex- and reward-dependent effects of early life scarcity-adversity on adolescent behavioral responses to natural rewards.Frontiers in behavioral neuroscience · 2025Article
- The Impact of Social Media & Technology on Child and Adolescent Mental Health.Journal of psychiatry and psychiatric disorders · 2025Article
- Adolescent mice exhibit lower reward sensitivity than adults.Frontiers in behavioral neuroscience · 2025Article
- Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression.Molecular psychiatry · 2023Article
- Mood and behavior regulation: interaction of lithium and dopaminergic system.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Propensity for risky choices despite lower cue reactivity in adolescent rats.Frontiers in behavioral neuroscience · 2023Article
- Reward-motivated memories influence new learning across development.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Flexibility in valenced reinforcement learning computations across development.Child development · 2022Article
- Reward Enhances Memory via Age-Varying Online and Offline Neural Mechanisms across Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adolescence is an evolutionarily conserved developmental period, with neural circuits and behaviors contributing to the detection, procurement, and receipt of rewards bearing similarity across species. Studies with laboratory animals suggest that adolescence is typified by a "reward-centric" phenotype-an increased sensitivity to rewards relative to adults. In contrast, adolescent rodents are reportedly less sensitive to the aversive properties of many drugs and naturally aversive stimuli. Alterations within the mesocorticolimbic dopamine and endocannabinoid systems likely contribute to an adolescent reward-sensitive, yet aversion-resistant, phenotype. Although early hypotheses postulated that developmental changes in dopaminergic circuitry would result in a "reward deficiency" syndrome, evidence now suggests the opposite: that adolescents are uniquely poised to seek out hedonic stimuli, experience greater "pleasure" from rewards, and consume rewarding stimuli in excess. Future studies that more clearly define the role of specific brain regions and neurotransmitter systems in the expression of behaviors toward reward- and aversive-related cues and stimuli are necessary to more fully understand an adolescent-proclivity for and vulnerability to rewards and drugs of potential abuse.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.