ArticleGenomics2016
Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa.
Article in Genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Association between weight cycling and risk of colorectal cancer: a prospective cohort study.British journal of cancer · 2024Article
- MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes.Endocrinology, diabetes & metabolism · 2022Review
- Constructing gene regulatory networks using epigenetic data.NPJ systems biology and applications · 2021Article
- Gene Targeting in Disease Networks.Frontiers in genetics · 2021Article
- Different Biological Pathways Between Good and Poor Inhaled Corticosteroid Responses in Asthma.Frontiers in medicine · 2021Article
- Molecular networks in Network Medicine: Development and applications.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- PUMA: PANDA Using MicroRNA Associations.Bioinformatics (Oxford, England) · 2020Article
- Network Medicine in the Age of Biomedical Big Data.Frontiers in genetics · 2019Review
- Understanding Tissue-Specific Gene Regulation.Cell reports · 2017Article
- Estimating gene regulatory networks with pandaR.Bioinformatics (Oxford, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWeight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorectum is not well understood. We used integrative network modeling, Passing Attributes between Networks for Data Assimilation, to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women.
resultsWe identified significantly greater regulatory targeting of glucose transport pathways in the post-weight loss regulatory network, including "regulation of glucose transport" (FDR=0.02), "hexose transport" (FDR=0.06), "glucose transport" (FDR=0.06) and "monosaccharide transport" (FDR=0.08). These findings were not evident by gene expression analysis alone. Network analysis also suggested a regulatory switch from NFΚB1 to MAX control of MYC post-weight loss.
conclusionsThese network-based results expand upon standard gene expression analysis by providing evidence for a potential mechanistic alteration caused by weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.