ArticleCurrent biology : CB2016
Mismatch of Synaptic Patterns between Neurons Produced in Regeneration and during Development of the Vertebrate Retina.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Article
- Study on the protective effects and mechanisms of eleutherococcus senticosus on korsakoff syndrome.Frontiers in neuroscience · 2025Review
- The impact of timing and injury mode on induced neurogenesis in the adult mammalian retina.Stem cell reports · 2024Article
- Intrinsic and Induced Neuronal Regeneration in the Mammalian Retina.Antioxidants & redox signaling · 2023Review
- Cell-Based Therapies: Strategies for Regeneration.Cold Spring Harbor perspectives in medicine · 2023Review
- Assessing Rewiring of the Retinal Circuitry by Electroretinogram (ERG) After Inner Retinal Lesion in Adult Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Live Cell Imaging of Dynamic Processes in Adult Zebrafish Retinal Cross-Section Cultures.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Generating Widespread and Scalable Retinal Lesions in Adult Zebrafish by Intraocular Injection of Ouabain.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Eye flukes (Diplostomum spp) damage retinal tissue and may cause a regenerative response in wild threespine stickleback fish.Experimental eye research · 2022Article
- Comparative Biology of Vertebrate Retinal Regeneration: Restoration of Vision through Cellular Reprogramming.Cold Spring Harbor perspectives in biology · 2022Review
- Retinal regeneration requires dynamic Notch signaling.Neural regeneration research · 2022Review
- Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration.Molecular neurobiology · 2022Review
- Dynamic functional and structural remodeling during retinal regeneration in zebrafish.Frontiers in molecular neuroscience · 2022Article
- Evidence of regional specializations in regenerated zebrafish retina.Experimental eye research · 2021Review
- Review
- Conditional and biased regeneration of cone photoreceptor types in the zebrafish retina.The Journal of comparative neurology · 2020Article
- Noninvasive Imaging of Cone Ablation and Regeneration in Zebrafish.Translational vision science & technology · 2020Article
- The Regenerating Adult Zebrafish Retina Recapitulates Developmental Fate Specification Programs.Frontiers in cell and developmental biology · 2020Article
- Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion.Frontiers in cell and developmental biology · 2019Article
- Stereotyped Synaptic Connectivity Is Restored during Circuit Repair in the Adult Mammalian Retina.Current biology : CB · 2018Article
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4 authors.
Funding
Abstract
Stereotypic patterns of synaptic connections between neurons underlie the ability of the CNS to perform complex but circuit-specific information processing. Tremendous progress has been made toward advancing our understanding of how circuits are assembled during development, but whether the precision of this process can be recaptured after regeneration of neurons in the damaged CNS remains unclear. Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconstruct the circuitry of neurons produced after damage. We tracked the input connectivity of identified bipolar cell (BC) types across stages of retinal development and after BC regeneration. We found that BCs of each type generate a unique and stereotypic wiring pattern with cone photoreceptors by gaining synapses with specific photoreceptor types over time. After selective ablation, the targeted BC types are rapidly reproduced and largely re-establish their characteristic morphological features. The regenerated population connects with appropriate photoreceptor types and establishes the original number of synaptic contacts. However, BC types that normally bias their connectivity in favor of red cones fail to precisely recapture this synaptic partner preference upon regeneration. Furthermore, regenerated BCs succeed in forming synaptic specializations at their axon terminals, but in excess of the usual number. Altogether, we find that regenerated BCs reinstate some, but not all, major features of their stereotypic wiring, suggesting that circuit patterns may be unable to regenerate with the same fidelity as in development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.