Evidence map›Paper›PMID 27524448›Full record

ReviewClinics in perinatology2016

Cardiovascular Alterations and Multiorgan Dysfunction After Birth Asphyxia.

Graeme R Polglase, Tracey Ong, Noah H Hillman

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  4. Fetomaternal hemorrhage: pathogenesis, diagnosis, and clinical management.Journal of perinatology : official journal of the California Perinatal Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Graeme R PolglaseThe Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia. Electronic address: graeme.polglase@monash.edu.
Tracey OngThe Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia.
Noah H HillmanDepartment of Pediatrics, Saint Louis University, 1100 South Grand Boulevard, St Louis, MO 63124, USA.
Hudson Institute of Medical Research · AUSaint Louis University · US

Funding

Facilitating The Physiological Transition at Birth In Term And Preterm NeonatesR01HD072848 · NICHD · MONASH UNIVERSITY · PI DAVIS, PETER GRAHAM, HOOPER, STUART · 2013 to 2016
$1.5M
NICHD NIH HHS R01 HD072848
6 · The paper itself

Abstract

The cardiovascular response to asphyxia involves redistribution of cardiac output to maintain oxygen delivery to critical organs such as the adrenal gland, heart, and brain, at the expense of other organs such as the gut, kidneys and skin. This redistribution results in reduced perfusion and localized hypoxia/ischemia in these organs, which, if severe, can result in multiorgan failure. Liver injury, coagulopathy, bleeding, thrombocytopenia, renal dysfunction, and pulmonary and gastrointestinal injury all result from hypoxia, underperfusion, or both. Current clinical therapies need to be considered together with therapeutic hypothermia and cardiovascular recovery.

Indexed as

Acute Kidney InjuryAsphyxia NeonatorumBlood Coagulation DisordersCardiovascular SystemFemaleGastrointestinal DiseasesHemorrhageHumansHypothermia, InducedHypoxia-Ischemia, BrainInfant, NewbornLiver DiseasesLung DiseasesMultiple Organ FailurePregnancyThrombocytopeniaAsphyxiaCardiovascularKidneysLiverMultiorgan failure

Identifiers

PMID27524448
PMCPMC4988334
OpenAlexW2464282026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.