Evidence map›Paper›PMID 27524410›Full record

ArticleMolecular and cellular endocrinology2016

Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.

Justyna M Wierzbicka, Michał A Żmijewski, Anna Piotrowska, Boguslaw Nedoszytko, Magdalena Lange, Robert C Tuckey, Andrzej T Slominski

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. 1,24,25(OH)Scientific reports · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Dithiothreitol reduces oxidative stress and necrosis caused by ultraviolet A radiation in L929 fibroblasts.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. The serum vitamin D metabolome: What we know and what is still to discover.The Journal of steroid biochemistry and molecular biology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Justyna M WierzbickaDepartment of Histology, Medical University of Gdańsk, Poland.
Michał A ŻmijewskiDepartment of Histology, Medical University of Gdańsk, Poland. Electronic address: mzmijewski@gumed.edu.pl.
Anna PiotrowskaDepartment of Histology, Medical University of Gdańsk, Poland.
Boguslaw NedoszytkoDepartment and Clinic of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland.
Magdalena LangeDepartment and Clinic of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland.
Robert C TuckeySchool of Chemistry and Biochemistry, The University of Western Australia, Crawley, Perth, WA 6009, Australia.
Andrzej T SlominskiDepartment of Dermatology, University of Alabama Birmingham, Birmingham, AL 35294, USA; Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama Birmingham, Birmingham, AL 35294, USA; VA Medical Center, Birmingham, AL 35294, USA.
Gdańsk Medical University · PLThe University of Western Australia · AUUniversity of Alabama at Birmingham · US

Funding

Novel Biosynthetic Pathway for Secosteroids and the SkinR01AR052190 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI POSTLETHWAITE, ARNOLD E, SLOMINSKI, ANDRZEJ T · 2006 to 2013
$2.2M
Role of Exogenous Melatonin in Skin BiologyR01AR056666 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2011 to 2015
$1.6M
Mechanism of action of 20-hydroxyvitamin D3 in dermal fibroblastsR21AR066505 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2014 to 2015
$355k
NIAMS NIH HHS R01 AR052190NIAMS NIH HHS R01 AR056666NIAMS NIH HHS R21 AR066505
6 · The paper itself

Abstract

Ultraviolet radiation B stimulates both the production of vitamin D

Indexed as

Epidermal CellsAdrenocorticotropic HormoneBlotting, WesternCalciumCell DifferentiationCell LineCell ProliferationCholecalciferolHumansHypothalamo-Hypophyseal SystemKeratinocytesPituitary-Adrenal SystemReceptor, Melanocortin, Type 2Vitamin DAdrenocorticotropic HormoneCalciumCholecalciferolReceptor, Melanocortin, Type 2Vitamin DCalciumCorticotropin releasing factorHPA axisKeratinocytes differentiationVitamin D(3)Vitamin D(3) analogs

Identifiers

PMID27524410
PMCPMC5048597
OpenAlexW2513643662

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.