ArticleThe British journal of radiology2017
MRI-guided radiotherapy of the SK-N-SH neuroblastoma xenograft model using a small animal radiation research platform.
Article in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- In-silico evaluation of the effect of set-up errors on dose delivery during mouse irradiations with a Cs-137 cell irradiator-based collimator system.Physical and engineering sciences in medicine · 2025Article
- Development of Total Lymphoid Irradiation (TLI)-Dedicated Shielding and Image-Guided System and Dose Evaluation Using 3D-Printed Rat Phantom.Frontiers in veterinary science · 2022Article
- A simple, open and extensible gating Control unit for cardiac and respiratory synchronisation control in small animal MRI and demonstration of its robust performance in steady-state maintained CINE-MRI.Magnetic resonance imaging · 2021Article
- MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?Frontiers in oncology · 2020Review
- Reduced respiratory motion artefact in constant TR multi-slice MRI of the mouse.Magnetic resonance imaging · 2019Article
- Velocity-based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform.International journal of radiation oncology, biology, physics · 2018Article
- Article
- PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator.Journal of visualized experiments : JoVE · 2017Article
- Automated MicroSPECT/MicroCT Image Analysis of the Mouse Thyroid Gland.Thyroid : official journal of the American Thyroid Association · 2017Article
- Improved outcome ofRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2017Article
- An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.PloS one · 2017Article
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Authors and funding
14 authors.
Funding
Abstract
objectiveNeuroblastoma has one of the lowest survival rates of all childhood cancers, despite the use of intensive treatment regimens. Preclinical models of neuroblastoma are essential for testing new multimodality protocols, including those that involve radiotherapy (RT). The aim of this study was to develop a robust method for RT planning and tumour response monitoring based on combined MRI and cone-beam CT (CBCT) imaging and to apply it to a widely studied mouse xenograft model of neuroblastoma, SK-N-SH.
methodsAs part of a tumour growth inhibition study, SK-N-SH xenografts were generated in BALB/c nu/nu mice. Mice (n = 8) were placed in a printed MR- and CT-compatible plastic cradle, imaged using a 4.7-T MRI scanner and then transferred to a small animal radiation research platform (SARRP) irradiator with on-board CBCT. MRI/CBCT co-registration was performed to enable RT planning using the soft-tissue contrast afforded by MRI prior to delivery of RT (5 Gy). Tumour response was assessed by serial MRI and calliper measurements.
resultsSK-N-SH xenografts formed soft, deformable tumours that could not be differentiated from surrounding normal tissues using CBCT. MR images, which allowed clear delineation of tumours, were successfully co-registered with CBCT images, allowing conformal RT to be delivered. MRI measurements of tumour volume 4 days after RT correlated strongly with length of survival time.
conclusionMRI allowed precision RT of SK-N-SH tumours and provided an accurate means of measuring tumour response. Advances in knowledge: MRI-based RT planning of murine tumours is feasible using an SARRP irradiator.
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