Evidence map›Paper›PMID 27524296›Full record

ArticleCell chemical biology2016

Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation.

Jakob Fuhrmann, Venkataraman Subramanian, Douglas J Kojetin, Paul R Thompson

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. The Transcriptomic Response of Cells of the Thermophilic BacteriumInternational journal of molecular sciences · 2024
    Article
  4. Review
  5. Structural insights into the regulation of protein-arginine kinase McsB by McsA.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Synthesis and Evaluation of Non-Hydrolyzable Phospho-Lysine Peptide Mimics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Protein post-translational modifications in bacteria.Nature reviews. Microbiology · 2019
    Review
  17. Arginine dephosphorylation propels spore germination in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Article
  19. Review
  20. Spectral Library Based Analysis of Arginine Phosphorylations inMolecular & cellular proteomics : MCP · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jakob FuhrmannDepartment of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
Venkataraman SubramanianDepartment of Biochemistry and Molecular Pharmacology, UMass Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Program in Chemical Biology, UMass Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Douglas J KojetinDepartment of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
Paul R ThompsonDepartment of Biochemistry and Molecular Pharmacology, UMass Medical School, 364 Plantation Street, Worcester, MA 01605, USA; Program in Chemical Biology, UMass Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address: paul.thompson@umassmed.edu.
Scripps Research Institute · USUniversity of Massachusetts Chan Medical School · US

Funding

Chemical probes to decipher PAD biologyR35GM118112 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Paul R Thompson · 2016 to 2026
$9.5M
Haloacetamidine based inactivators of Protein Arginine Deiminase 4R01GM079357 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THOMPSON, PAUL R · 2007 to 2016
$3.3M
Identification of Citrullinated Biomarkers of Inflammatory Disease and CancerR01GM110394 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THOMPSON, PAUL R · 2014 to 2016
$1.7M
NIGMS NIH HHS R01 GM079357NIGMS NIH HHS R01 GM110394NIGMS NIH HHS R35 GM118112
6 · The paper itself

Abstract

Protein arginine phosphorylation is a recently discovered modification that affects multiple cellular pathways in Gram-positive bacteria. In particular, the phosphorylation of arginine residues by McsB is critical for regulating the cellular stress response. Given that the highly efficient protein arginine phosphatase YwlE prevents arginine phosphorylation under non-stress conditions, we hypothesized that this enzyme negatively regulates arginine phosphorylation and acts as a sensor of cell stress. To evaluate this hypothesis, we developed the first suite of highly potent and specific SO

Indexed as

AmidinesArginineBacillus subtilisBacterial ProteinsDose-Response Relationship, DrugEnzyme InhibitorsGeobacillus stearothermophilusModels, MolecularMolecular ConformationOxidative StressPhosphoprotein PhosphatasesPhosphorylationStructure-Activity RelationshipSulfur OxidesAmidinesArginineBacterial ProteinsEnzyme InhibitorsPhosphoprotein PhosphatasesSulfur Oxidessulfur trioxide

Identifiers

PMID27524296
PMCPMC5157131
OpenAlexW2513016959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.