ArticleDental materials : official publication of the Academy of Dental Materials2016
Experimental primers containing synthetic and natural compounds reduce enzymatic activity at the dentin-adhesive interface under cyclic loading.
Article in Dental materials : official publication of the Academy of Dental Materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.Odontology · 2025Pooled it
- Long-term nano-dynamic mechanical analysis and micro-permeability of adhesive interface components using four AB-type proanthocyanidin neutral primers.Journal of dentistry · 2026Article
- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.Clinical oral investigations · 2024Article
- Effect of the use of bromelain associated with bioactive glass-ceramic on dentin/adhesive interface.Clinical oral investigations · 2024Article
- Fucosterol and Fucoxanthin Enhance Dentin Collagen Stability and Erosion Resistance Through Crosslinking and MMP Inhibition.International journal of nanomedicine · 2024Article
- Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion.Molecular pharmaceutics · 2022Article
- Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen-rich dentin.Journal of biomedical materials research. Part A · 2022Article
- Development of an antibacterial and anti-metalloproteinase dental adhesive for long-lasting resin composite restorations.Journal of materials chemistry. B · 2020Article
- Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive.Dental materials : official publication of the Academy of Dental Materials · 2020Article
- Effect of thermo-mechanical cycling and chlorhexidine on the bond strength of universal adhesive system to dentin.Heliyon · 2020Article
- Dimeric Proanthocyanidins on the Stability of Dentin and Adhesive Biointerfaces.Journal of dental research · 2020Article
- Evidence to the role of interflavan linkages and galloylation of proanthocyanidins at sustaining long-term dentin biomodification.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Recent Advances in Adhesive Bonding - The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates.Current oral health reports · 2017Article
- Shear bond strength of the adhesive/dentin interface after different etching protocols.Journal of conservative dentistry : JCDArticle
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo evaluate the effect of experimental primers (chlorhexidine, enriched mixture of proanthocyanidins, and doxycycline) on the adhesive properties and gelatinolytic activity at dentin-resin interfaces of occlusal Class I restorations.
methodsThe inactivation of enzymes by the experimental primers was assessed by fluorescence assay and gelatin zymography. To assess the adhesive properties, occlusal Class I cavities were prepared in sound human molars, etched with phosphoric acid and restored with one of the primers and an etch-and-rinse adhesive system (Adper Single Bond Plus-3M ESPE). After the restorative procedures, specimens were divided into two subgroups (n=6) consisting of storage in incubation buffer or axial cyclic loading at 50N and 1,000,000 cycles. Then, the specimens were sectioned and slices were assigned to in situ zymography assay and microtensile bond strength (TBS) test.
resultsFluorescence assay and gelatin zymography revealed that the experimental primers inactivated rMMPs. In situ zymography (2-way ANOVA, Tukey, p<0.05) showed that cyclic loading increased the gelatinolytic activity at the resin-dentin interface and the experimental primers decreased the gelatinolytic activity at the adhesive interface. The experimental primers had no significant effects on dentin-adhesive bond strengths with or without cyclic loading (2-way ANOVA, p>0.05). SIGNIFICANCE: The use of experimental primers impaired the enzymatic activity at the dentin-adhesive interface after cyclic loading and the activity of rMMPs. Cyclic loading did not have a significant effect on the bond strength.
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