ArticleMaterials science & engineering. C, Materials for biological applications2016
Hydroxyapatite coating on PEEK implants: Biomechanical and histological study in a rabbit model.
Article in Materials science & engineering. C, Materials for biological applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- Polyetheretherketone (PEEK) in maxillofacial reconstruction surgery: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Surface Modification of Cranioplasty Implants to Reduce Postoperative Cerebrospinal Fluid Collection: A Preliminary Clinical Study.Korean journal of neurotrauma · 2026Article
- Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment.Scientific reports · 2025Article
- Evolution of Anchor Polymer Systems Used in Arthroscopic Shoulder Surgery-A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2025Review
- Unveiling the characteristics and surface modification of titanium, zirconia, and polyetheretherketone dental implants.Journal of dental sciences · 2025Review
- Biocompatible Thermoplastics in Additive Manufacturing of Bone Defect Fillers: State-of-the-Art and Future Prospects.Materials (Basel, Switzerland) · 2025Review
- [Research progress on enhancing osseointegration properties of polyetheretherketone implants through various modification methods].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Bone Regeneration: Mini-Review and Appealing Perspectives.Bioengineering (Basel, Switzerland) · 2025Review
- Green Synthesis of Ag and Cu Nanoparticles UsingMaterials (Basel, Switzerland) · 2024Article
- Characterization and biocompatibility of a bilayer PEEK-based scaffold for guiding bone regeneration.BMC oral health · 2024Article
- Chemically heparinized PEEKRSC advances · 2024Article
- Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation-fiction or reality?Frontiers in surgery · 2024Review
- Performance of 3D printed porous polyetheretherketone composite scaffolds combined with nano-hydroxyapatite/carbon fiber in bone tissue engineering: a biological evaluation.Frontiers in bioengineering and biotechnology · 2024Article
- Balancing beauty and science: a review of facial implant materials in craniofacial surgery.Frontiers in surgery · 2024Review
- Latest advances: Improving the anti-inflammatory and immunomodulatory properties of PEEK materials.Materials today. Bio · 2023Review
- Assessing biocompatibility & mechanical testing of 3D-printed PEEK versus milled PEEK.Heliyon · 2022Article
- Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants.Materials today. Bio · 2022Review
- Effect of Extreme Ultraviolet (EUV) Radiation and EUV Induced, NInternational journal of molecular sciences · 2021Article
- Controlled biointerfaces with biomimetic phosphorus-containing polymers.Science and technology of advanced materials · 2021Review
- Biological Safety Evaluation and Surface Modification of Biocompatible Ti-15Zr-4Nb Alloy.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A bioactive two-layer coating consisting of hydroxyapatite (HA) and yttria-stabilized zirconia (YSZ) was investigated on cylindrical polyetheretherketone (PEEK) implants using ion beam assisted deposition (IBAD). Post-deposition heat treatments via variable frequency microwave annealing with and without subsequent autoclaving were used to crystallize the as-deposited amorphous HA layer. Microstructural analysis, performed by TEM and EDS, showed that these methods were capable of crystallizing HA coating on PEEK. The in vivo response to cylindrical PEEK samples with and without coating was studied by implanting uncoated PEEK and coated PEEK implants in the lateral femoral condyle of 18 rabbits. Animals were studied in two groups of 9 for observation at 6 or 18weeks post surgery. Micro-CT analysis, histology, and mechanical pull-out tests were performed to determine the effect of the coating on osseointegration. The heat-treated HA/YSZ coatings showed improved implant fixation as well as higher bone regeneration and bone-implant contact area compared to uncoated PEEK. The study offers a novel method to coat PEEK implants with improved osseointegration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.