ArticleHeart rhythm2016
Tpeak-to-Tend interval corrected for heart rate: A more precise measure of increased sudden death risk?
Article in Heart rhythm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
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- Electrocardiographic predictors of ventricular arrhythmic events in ICD recipients: signal beyond the left ventricular ejection fraction threshold.BMC cardiovascular disorders · 2026Article
- Markers of sudden cardiac death associated with the ventricular-paced 12-lead ECG.European heart journal open · 2025Article
- Nanoscale piezoelectric patches preserve electrical integrity of infarcted hearts.Materials today. Bio · 2025Article
- Age-Associated Perinexal Narrowing Masks Consequences of Sodium Channel Gain of Function in Guinea Pig Hearts.JACC. Clinical electrophysiology · 2025Article
- Unsupervised clustering of single-lead electrocardiograms associates with prevalent and incident heart failure in coronary artery disease.European heart journal. Digital health · 2025Article
- Clinical, Electrical, and Mechanical Parameters in Potassium Channel-Mediated Congenital Long QT Syndrome.Journal of clinical medicine · 2025Article
- Article
- Effect of Remifentanil on the Tpeak-Tend Interval During Electroconvulsive Therapy.Advances in therapy · 2024Article
- Correlation between frontal QRS-T angle, Tp-e interval, and Tp-e/QT ratio to coronary artery severity assessed with SYNTAX score in stable coronary artery disease patients.Journal of arrhythmia · 2022Article
- Evaluation of the Cardiac Conduction System in Fibromyalgia Patients With Complaints of Palpitations.Cureus · 2022Article
- Plasma potassium concentration and cardiac repolarisation markers, TEuropean journal of applied physiology · 2022Article
- Electrocardiography clues in assessment of patients with premature ventricular contractionsTurkish journal of medical sciences · 2021Article
- Disease Severity Affects Ventricular Repolarization Parameters in Patients With COVID-19.Arquivos brasileiros de cardiologia · 2020Article
- Heart Rate Dependency and Inter-Lead Variability of the T Peak - T End Intervals.Frontiers in physiology · 2020Article
- Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals.Scientific reports · 2019Article
- Can abnormal dispersion of ventricular repolarization be a predictor of mortality in arrhythmogenic right ventricular cardiomyopathy: The importance of Tp-e interval.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Assessment of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Aortic Aneurysm.Open access Macedonian journal of medical sciences · 2019Article
- Comparing of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Preserved, Mid-Range and Reduced Ejection Fraction Heart Failure.Open access Macedonian journal of medical sciences · 2019Article
- Insulin Resistance is Associated with Longitudinal Changes of Cardiac Repolarization Heterogeneity in Apparently Healthy Subjects.Cardiology and therapy · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec).
objectivesWe evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk.
methodsCases of SCA (n = 628; mean age 66.4 ± 14.5 years; n = 416, 66.2% men) from the Oregon Sudden Unexpected Death Study with an archived electrocardiogram available prior and unrelated to the SCA event were analyzed. Comparisons were made with control subjects (n = 819; mean age 66.7 ± 11.5 years; n = 559, 68.2% men). The Tpe interval was corrected for heart rate using Bazett (TpecBa) and Fridericia (TpecFd) formulas, and the predictive value of Tpec for SCA was evaluated using logistic regression models.
resultsThe area under the curve for Tpec predicting SCA improved with both correction formulas. TpecBa and TpecFd were shown to have an area under the curve of 0.695 and 0.672, respectively, as compared with a baseline of 0.601 with an uncorrected Tpe. A TpecBa value of >90 ms was predictive of SCA, independent of age, sex, comorbidities, QRS duration, corrected QT interval, and severely reduced left ventricular ejection fraction (≤35%; odds ratio 2.8; 95% confidence interval 1.92-4.17; P < .0001).
conclusionCorrecting Tpe for heart rate, using either the Bazett or the Fridericia formula, improved the independent predictive value of this marker for the assessment of SCA risk. Prolongation of TpecBa beyond 90 ms was associated with a nearly 3-fold increased risk of SCA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.