Evidence map›Paper›PMID 27523501›Full record

ArticleThe American journal of psychiatry2016

Early Improvement in Work Productivity Predicts Future Clinical Course in Depressed Outpatients: Findings From the CO-MED Trial.

Manish K Jha, Abu Minhajuddin, Tracy L Greer, Thomas Carmody, A John Rush, Madhukar H Trivedi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Manish K JhaFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
Abu MinhajuddinFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
Tracy L GreerFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
Thomas CarmodyFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
A John RushFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
Madhukar H TrivediFrom the Departments of Psychiatry and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas; and the National University of Singapore, Singapore.
The University of Texas Southwestern Medical Center · US

Funding

TREATMENT RESISTANT DEPRESSION-278990003N01MH090003 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · 1999 to 2003
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NIMH NIH HHS N01 MH090003
6 · The paper itself

Abstract

objectiveDepression symptom severity, the most commonly studied outcome in antidepressant treatment trials, accounts for only a small portion of burden related to major depression. While lost work productivity is the biggest contributor to depression's economic burden, few studies have systematically evaluated the independent effect of treatment on work productivity and the relationship between changes in work productivity and longer-term clinical course.

methodWork productivity was measured repeatedly by the Work Productivity and Activity Impairment self-report questionnaire in 331 employed participants with major depression enrolled in the Combining Medications to Enhance Depression Outcomes trial. Trajectories of change in work productivity during the first 6 weeks of treatment were identified and used to predict remission at 3 and 7 months.

resultsParticipants reported reduced absence from work and increased work productivity with antidepressant treatment even after controlling for changes in depression severity. Three distinct trajectories of changes in work productivity were identified: 1) robust early improvement (24%), 2) minimal change (49%), and 3) high-impairment slight reduction (27%). Compared with other participants, those with robust improvement had 3-5 times higher remission rates at 3 months and 2-5 times higher remission rates at 7 months, even after controlling for select baseline variables and remission status at week 6.

conclusionsIn this secondary analysis, self-reported work productivity improved in depressed patients with antidepressant treatment even after accounting for depressive symptom reduction. Early improvement in work productivity is associated with much higher remission rates after 3 and 7 months of treatment.

Indexed as

EfficiencyAdultAntidepressive AgentsDrug Therapy, CombinationFemaleHumansMajor Depressive DisorderMalePrognosisRemission InductionYoung AdultAntidepressive Agents

Identifiers

PMID27523501
PMCPMC5895453
OpenAlexW2515806906

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.