ArticleIntegrative biology : quantitative biosciences from nano to macro2016
Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform.
Article in Integrative biology : quantitative biosciences from nano to macro, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells.Drug delivery and translational research · 2024Article
- Engineering the human blood-brain barrier at the capillary scale using a double-templating technique.Advanced functional materials · 2022Article
- Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells.Applied sciences (Basel, Switzerland) · 2022Article
- Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo.Biomaterials · 2021Article
- Microfluidic Biomaterials.Advanced healthcare materials · 2021Review
- A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D.Fluids and barriers of the CNS · 2019Article
- Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered Three-Dimensional Microvessel Model of the Tumor Microenvironment.ACS biomaterials science & engineering · 2019Article
- Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior.Biomaterials · 2019Article
- Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation.Fluids and barriers of the CNS · 2018Article
- Tissue-engineered 3D microvessel and capillary network models for the study of vascular phenomena.Microcirculation (New York, N.Y. : 1994) · 2017Review
- Engineering the human blood-brain barrier in vitro.Journal of biological engineering · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Here we report on real-time imaging and quantitative analysis of solute transport in perfusable cylindrical microvessels formed from Madin-Darby canine kidney (MDCK) cells embedded in a collagen matrix. Fluorescence microscopy was used to image the kinetics of doxorubicin transport following injection. To assess the role of efflux pumps on transport, experiments were performed in microvessels formed from MDCK.2, MDCKII-w/t, and MDCKII-MDR1 cells. MDCKII-w/t and MDCKII-MDR1 showed significant doxorubicin accumulation in the cells, characteristic of the pharmacokinetics of doxorubicin. We present a model for doxorubicin transport that takes into account transport across the cell layer. These results demonstrate how real-time imaging of cell microvessels can be used to analyze the mechanisms of transport and distribution following systemic delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.