Evidence map›Paper›PMID 27523451›Full record

ReviewThe Kaohsiung journal of medical sciences2016

Therapeutic potential of melatonin in oral medicine and periodontology.

Shariq Najeeb, Zohaib Khurshid, Sana Zohaib, Muhammad Sohail Zafar

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Kaohsiung journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03833570 (The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03833570 phase2completednot on this mapstarted 2018, after this paper: background citation

The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis

TypeinterventionalSponsorHams Hamed AbdelrahmanRan2018 to 2018Enrolled40ConditionsOral Mucositis (Ulcerative) Due to RadiationArmsRapid Release Capsules Melatonin, 10 mg, Miconaz oral gel, BBC oral spray, Oracure gel, Alkamisr sachets
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 57 citations in OpenAlex.

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  17. The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020
    Article
  18. Article
  19. Review
  20. Efficacy of metformin in the management of periodontitis: A systematic review and meta-analysis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Shariq NajeebDepartment of Dentistry, Riyadh Consultative Clinics, Imam Saud Road, Al Murooj, Riyadh, Saudi Arabia. Electronic address: shariqnajeeb@gmail.com.
Zohaib KhurshidDepartment of Dental Biomaterials, College of Dentistry, King Faisal University, Al-Hofuf, Saudi Arabia.
Sana ZohaibDepartment of Biomedical Engineering, College of Engineering, King Faisal University, Al-Hofuf, Saudi Arabia.
Muhammad Sohail ZafarDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Madina Munawwarah, Saudi Arabia.
King Faisal University · SAImam Mohammad ibn Saud Islamic University · SATaibah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a number of conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration. The aim of this review is to critically analyze and summarize the research focusing on the potential of melatonin in the field of oral medicine. Topical administration of melatonin has a positive effect on periodontal health and osseointegration. Furthermore, melatonin is particularly effective in improving the periodontal parameters of diabetic patients with periodontitis. Melatonin exerts a regenerative effect on periodontal bone and may be incorporated into of periodontal scaffolds. The cytotoxic effect of various drugs and dental materials may be countered by the antioxidant properties of melatonin. Topical administration of melatonin promotes the healing of tooth extraction sockets and may also impede the progression of oral cancer. Although, there are a number of current and potential applications of melatonin, further long term clinical and animal studies are needed to assess its efficacy. Moreover, the role of melatonin supplements in the management of periodontitis should also be assessed.

Indexed as

Oral MedicineAnimalsBone RegenerationHumansMelatoninOsseointegrationPeriodontal DiseasesMelatoninAntioxidantsMelatoninOral cancerOsseointegrationPeriodontitis

Identifiers

PMID27523451
PMCPMC11916563
OpenAlexW2493363309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.