Evidence map›Paper›PMID 27523440›Full record

ArticlePractical radiation oncology

Distortion inherent to magnetic resonance imaging can lead to geometric miss in radiosurgery planning.

Tyler M Seibert, Nathan S White, Gwe-Ya Kim, Vitali Moiseenko, Carrie R McDonald, Nikdokht Farid, Hauke Bartsch, Joshua Kuperman, Roshan Karunamuni, Deborah Marshall and 6 more

Abstract read
In one paragraph

Article in Practical radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tyler M SeibertDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Nathan S WhiteDepartment of Radiology, University of California, San Diego, La Jolla, California.
Gwe-Ya KimDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Vitali MoiseenkoDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Carrie R McDonaldDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California; Department of Psychiatry, University of California, San Diego, La Jolla, California.
Nikdokht FaridDepartment of Radiology, University of California, San Diego, La Jolla, California.
Hauke BartschDepartment of Radiology, University of California, San Diego, La Jolla, California.
Joshua KupermanDepartment of Radiology, University of California, San Diego, La Jolla, California.
Roshan KarunamuniDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Deborah MarshallDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Dominic HollandDepartment of Radiology, University of California, San Diego, La Jolla, California.
Parag SanghviDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Daniel R SimpsonDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Arno J MundtDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California.
Anders M DaleDepartment of Radiology, University of California, San Diego, La Jolla, California; Department of Neurosciences, University of California, San Diego, La Jolla, California.
Jona A Hattangadi-GluthDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California. Electronic address: jhattangadi@ucsd.edu.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
San Diego Clinical and Translational Research InstituteKL2TR000099 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$1.1M
San Diego Clinical and Translational Research InstituteKL2RR031978 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$615k
NCATS NIH HHS KL2 TR000099NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR001442NCRR NIH HHS KL2 RR031978
6 · The paper itself

Abstract

purposeAnatomic distortion is present in all magnetic resonance imaging (MRI) data because of nonlinearity of gradient fields; it measures up to several millimeters. We evaluated the potential for uncorrected MRI to lead to geometric miss of the target volume in stereotactic radiosurgery (SRS). METHODS AND MATERIALS: Twenty-eight SRS cases were studied retrospectively. MRI scans were corrected for gradient nonlinearity distortion in 3 dimensions, and gross tumor volumes (GTVs) were contoured. The manufacturer-specified distortion field was then reapplied to GTV masks to allow measurement of GTV displacement in uncorrected images. The uncorrected GTV was used for SRS planning, and the dose received by the true (corrected) GTV was measured.

resultsMedian displacement of the GTV resulting from gradient distortion was 1.2 mm (interquartile range, 0.1-2.3 mm), with a minimum of 0 mm and a maximum of 3.9 mm. Eight of the 28 cases met a priori criteria for "geometric miss."

conclusionsAlthough MRI distortion is often subtle on visual inspection, there is a significant clinical impact of this distortion on SRS planning. Distortion-corrected MRI should uniformly be used for intracranial radiosurgery planning because uncorrected MRI can lead to potential geometric miss.

Indexed as

Brain NeoplasmsHumansMagnetic Resonance ImagingPatient PositioningRadiosurgeryRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedRetrospective StudiesTumor Burden

Identifiers

PMID27523440
PMCPMC5099096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.