ArticlePsychological medicine2016
Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm.
Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Atypical neural responses to dynamically changing facial expressions correlate with behavioral risk in toddlers born preterm: Evidence from an ERP study.Neuroimage. Reports · 2026Article
- Covid-19 pandemic in children born very premature with dysexecutive disorders: impact of isolation measures and/or neurobehavioral phenotype? A cross sectional study.Pediatric research · 2026Article
- Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.Neurophotonics · 2026Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants.Computer methods and programs in biomedicine · 2024Article
- Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.Pediatric research · 2024Article
- Face Processing in Prematurely Born Individuals-A Systematic Review.Brain sciences · 2024Review
- Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents.Psychiatry and clinical neurosciences · 2024Article
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.Brain structure & function · 2024Article
- Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes: an exploratory study.Pediatric research · 2023Article
- Vulnerability of the Neonatal Connectome following Postnatal Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Social gaze in preterm infants may act as an early indicator of atypical lateralization.Child development · 2022Article
- Early-life stress exposure and large-scale covariance brain networks in extremely preterm-born infants.Translational psychiatry · 2022Article
- Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children.Brain communications · 2022Article
- Prediction of Facial Emotion Recognition Ability in Patients With First-Episode Schizophrenia Using Amplitude of Low-Frequency Fluctuation-Based Support Vector Regression Model.Frontiers in psychiatry · 2022Article
- Amygdala subnuclei volumes, functional connectivity, and social-emotional outcomes in children born very preterm.Cerebral cortex communications · 2022Article
- Altered functional connectivity during face processing in children born with very low birth weight.Social cognitive and affective neuroscience · 2021Article
- Social cognition in individuals born preterm.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundVery preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not been systematically studied. Here we investigated the functional integrity of the amygdala connectivity network in relation to the ability to recognize emotions from facial expressions in VPT adults.
methodThirty-six VPT-born adults and 38 age-matched controls were scanned at rest in a 3-T MRI scanner. Resting-state functional connectivity (rs-fc) was assessed with SPM8. A seed-based analysis focusing on three amygdalar subregions (centro-medial/latero-basal/superficial) was performed. Participants' ability to recognize emotions was assessed using dynamic stimuli of human faces expressing six emotions at different intensities with the Emotion Recognition Task (ERT).
resultsVPT individuals compared to controls showed reduced rs-fc between the superficial subregion of the left amygdala, and the right posterior cingulate cortex (p = 0.017) and the left precuneus (p = 0.002). The VPT group further showed elevated rs-fc between the left superficial amygdala and the superior temporal sulcus (p = 0.008). Performance on the ERT showed that the VPT group was less able than controls to recognize anger at low levels of intensity. Anger scores were significantly associated with rs-fc between the superficial amygdala and the posterior cingulate cortex in controls but not in VPT individuals.
conclusionsThese findings suggest that alterations in rs-fc between the amygdala, parietal and temporal cortices could represent the mechanism linking VPT birth and deficits in emotion processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.