Evidence map›Paper›PMID 27522659›Full record

ArticleInternational urology and nephrology2016

The effect of hypercalcemia on allograft calcification after kidney transplantation.

Aygül Çeltik, Sait Şen, Mümtaz Yılmaz, Meltem Seziş Demirci, Gülay Aşçı, Abdülkerim Furkan Tamer, Banu Sarsık, Cüneyt Hoşcoşkun, Hüseyin Töz, Ercan Ok

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Article in International urology and nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Aygül ÇeltikDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Sait ŞenDepartment of Pathology, School of Medicine, Ege University, Bornova, Izmir, 35100, Turkey.
Mümtaz YılmazDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Meltem Seziş DemirciDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Gülay AşçıDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Abdülkerim Furkan TamerDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Banu SarsıkDepartment of Pathology, School of Medicine, Ege University, Bornova, Izmir, 35100, Turkey.
Cüneyt HoşcoşkunDepartment of General Surgery, School of Medicine, Ege University, Bornova, Izmir, 35100, Turkey.
Hüseyin TözDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey. huseyin.toz@ege.edu.tr.
Ercan OkDivision of Nephrology, Department of Internal Medicine, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Ege University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePersistent hypercalcemia after kidney transplantation (KTx) may cause nephrocalcinosis and graft dysfunction. The aim of this study was to evaluate patients with hypercalcemia and assess its effect on tubulointerstitial calcification.

methodsA total of 247 recipients were enrolled. Transient and persistent hypercalcemia was defined as hypercalcemia (corrected serum calcium >10.2 mg/dL) persisting for 6 and 12 months after KTx, respectively. The severity of calcification in the 0-h, 6- and 12-month protocol biopsies of patients with transient (n = 8) and persistent hypercalcemia (n = 20) was compared with a matched control group (n = 28).

resultsTwenty-eight patients were hypercalcemic at 6 months posttransplantation. Serum calcium levels were normalized in eight of them at the end of the first year. Dialysis duration was a positive predictor of persistent hypercalcemia. Tubulointerstitial calcification was detected in 70.6 and 90 % of patients with persistent hypercalcemia at 6 and 12 months posttransplantation, respectively. In 20 % of patients with transient hypercalcemia, severity of calcification regressed at 12 months posttransplantation along with normalization of serum calcium levels. Graft functions and histopathological findings (ci, ct, ci + ct, cv, ah, percentage of sclerotic glomeruli) were not different at 6 and 12 months posttransplantation.

conclusionsHypercalcemia and persistent hyperparathyroidism are not rare after KTx. Tubulointerstitial calcification is more common and progressive among patients with persistent hypercalcemia. Normalization of calcium levels may contribute to regression of calcification in some patients.

Indexed as

AdultAllograftsCalciumCase-Control StudiesChronic DiseaseFemaleHumansHypercalcemiaKidney TransplantationMaleMiddle AgedNephrocalcinosisPostoperative PeriodCalciumGraft dysfunctionHypercalcemiaHyperparathyroidismKidney transplantationMicrocalcificationProtocol biopsy

Identifiers

PMID27522659
OpenAlexW2514576039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.