Evidence map›Paper›PMID 27522586›Full record

ArticleArchives of virology2016

A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis.

Tung Gia Phan, Kevin Messacar, Samuel R Dominguez, Antonio Charlys da Costa, Xutao Deng, Eric Delwart

Open access · greenAbstract readCase Reports
In one paragraph

Article in Archives of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. High-throughput sequencing for the aetiologic identification of viral encephalitis, meningoencephalitis, and meningitis. A narrative review and clinical appraisal.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019
    Review
  8. Article
  9. Review
  10. Encephalitis in US Children.Infectious disease clinics of North America · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tung Gia PhanBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Kevin MessacarChildren's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.
Samuel R DominguezChildren's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.
Antonio Charlys da CostaBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Xutao DengBlood Systems Research Institute, San Francisco, CA, 94118, USA.
Eric DelwartBlood Systems Research Institute, San Francisco, CA, 94118, USA. delwarte@medicine.ucsf.edu.
Blood Systems Research Institute · USChildren's Hospital Colorado · USUniversity of California, San Francisco · USUniversity of Colorado Denver · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS R01 HL105770
6 · The paper itself

Abstract

We characterized the genome of a densovirus, tentatively called human CSF-associated densovirus 1 (HuCSFDV1), in cerebrospinal fluid (CSF) from a human case of encephalitis with antibodies against the N-methyl D-aspartate receptor. The presence of the viral genome in CSF was independently confirmed. This virus, which is proposed to be a member of a new species in the genus Iteradensovirus of the subfamily Densovirinae, showed the typical two ORFs encoding nonstructural and structural proteins with low-level identities of 22 and 16 % to the closest known densovirus relative. No other eukaryotic viral sequences were detected using deep sequencing. The replication and pathogenicity in humans of this virus, which belongs to a viral subfamily whose members are only known to replicate in invertebrates, remain to be demonstrated. Alternative explanations for the detection of densovirus DNA in CSF are discussed.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisCerebrospinal FluidChildCluster AnalysisDensovirusDNA, ViralFemaleGenome, ViralHumansOpen Reading FramesPhylogenySequence Analysis, DNASequence HomologyDNA, Viral

Identifiers

PMID27522586
PMCPMC6550996
OpenAlexW2509812444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.