Evidence map›Paper›PMID 27522585›Full record

ArticleEuropean journal of applied physiology2016

Pro- and anti-inflammatory cytokine responses to a 164-km road cycle ride in a hot environment.

Hui-Ying Luk, Danielle E Levitt, Elaine C Lee, Matthew S Ganio, Brendon P McDermott, Brian R Kupchak, Brian K McFarlin, David W Hill, Lawrence E Armstrong, Jakob L Vingren

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The Role of Inflammation in Age-Related Macular Degeneration.International journal of biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui-Ying LukApplied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203-5017, USA.
Danielle E LevittApplied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203-5017, USA.
Elaine C LeeHuman Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA.
Matthew S GanioHuman Performance Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, 72701, USA.
Brendon P McDermottHuman Performance Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, 72701, USA.
Brian R KupchakDepartment of Military and Emergency Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, 20814, USA.
Brian K McFarlinApplied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203-5017, USA.
David W HillApplied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203-5017, USA.
Lawrence E ArmstrongHuman Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA.
Jakob L VingrenApplied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203-5017, USA. Jakob.Vingren@unt.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to examine the circulating cytokine response to a recreational 164-km road cycling event in a high ambient temperature and to determine if this response was affected by self-paced exercise time to completion.

methodsThirty-five men and five women were divided into tertiles based on time to complete the cycling event: slowest (SLOW), moderate (MOD), and fastest (FAST) finishers. Plasma samples were obtained 1-2 h before (PRE) and immediately after (IP) the event. A high-sensitivity multiplex assay kit was used to determine the concentration of plasma anti-inflammatory cytokines (IL-4, IL-5, IL-10, IL-13) and pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-7, IL-8, IL-12, GM-CSF, IFN-γ, and TNF-α).

resultsThe concentration of plasma IL-10 increased significantly (p < 0.05) in FAST and MOD groups and had no change in the SLOW group in response to a 164-km cycling event in the hot environment. Other cytokine responses were not influenced by the Time to completion. Pro-inflammatory cytokines IL-1β, IL-2, GM-CSF, and TNF-α decreased; whereas, IL-6 and IL-8 increased from PRE to IP. Additionally, anti-inflammatory cytokines IL-4 and IL-13 decreased.

conclusionsCompletion of a 164-km cycling event induced substantial changes in circulating pro- and anti-inflammatory cytokine concentrations. Time to completion appears to have a greater influence on the systemic IL-10 response than the environmental condition; however, it is possible that a threshold for absolute intensity must be reached for environmental conditions to affect the IL-10 response to exercise. Thus, cyclists from the FAST/MOD groups appear more likely to experience an acute transient immune suppression than cyclists from the SLOW group.

Indexed as

Anti-Inflammatory AgentsBicyclingCytokinesEcosystemFemaleHeat-Shock ResponseHot TemperatureHumansInflammation MediatorsMaleMiddle AgedPhysical EndurancePhysical ExertionAnti-Inflammatory AgentsCytokinesInflammation MediatorsAnti-inflammatory cytokineExerciseHeatImmune suppressionPro-inflammatory cytokineUltra-endurance

Identifiers

PMID27522585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.