Evidence map›Paper›PMID 27522537›Full record

Trial reportBrain and language2016

Transcranial direct current stimulation for the treatment of primary progressive aphasia: An open-label pilot study.

Felix Gervits, Sharon Ash, H Branch Coslett, Katya Rascovsky, Murray Grossman, Roy Hamilton

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and language, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05386394 (Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05386394 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2028Enrolled180ConditionsPrimary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive AphasiaArmsActive tDCS + Language Therapy, Sham tDCS + Language Therapy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. New Approaches to the Treatment of Frontotemporal Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Felix GervitsLaboratory for Cognition and Neural Stimulation, Center for Cognitive Neuroscience, University of Pennsylvania, United States; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, United States.
Sharon AshDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, United States; Penn Frontotemporal Degeneration Center, University of Pennsylvania, United States.
H Branch CoslettLaboratory for Cognition and Neural Stimulation, Center for Cognitive Neuroscience, University of Pennsylvania, United States; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, United States.
Katya RascovskyDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, United States; Penn Frontotemporal Degeneration Center, University of Pennsylvania, United States.
Murray GrossmanDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, United States; Penn Frontotemporal Degeneration Center, University of Pennsylvania, United States.
Roy HamiltonLaboratory for Cognition and Neural Stimulation, Center for Cognitive Neuroscience, University of Pennsylvania, United States; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, United States. Electronic address: roy.hamilton@uphs.upenn.edu.

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 1991 to 2020
$35.1M
TDP-43 Proteinopathies in ALS-DementiaP01AG032953 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2010 to 2014
$5.8M
Age, Hearing Loss, and Sentence Comprehension: Neural CorrelatesR01AG038490 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GROSSMAN, MURRAY · 2012 to 2016
$2.1M
NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG032953NIA NIH HHS P30 AG010124NIA NIH HHS R01 AG038490
6 · The paper itself

Abstract

Primary progressive aphasia (PPA) is a neurodegenerative condition characterized by gradual deterioration of language function. We investigated whether two weeks of daily transcranial direct current stimulation (tDCS) treatment would improve language abilities in six people with a non-fluent form of PPA. tDCS was applied in an unblinded trial at an intensity of 1.5mA for 20min/day over 10days. At the time of stimulation, patients were engaged in narrating one of several children's wordless picture stories. A battery of neuropsychological assessments was administered four times: at baseline, immediately following the 2-week stimulation period, and then 6-weeks and 12-weeks following the end of stimulation. We observed improvement in linguistic performance in the domains of speech production and grammatical comprehension. Our encouraging results indicate that larger, sham-controlled studies of tDCS as a potential intervention for PPA are warranted.

Indexed as

Transcranial Direct Current StimulationAgedAphasia, Primary ProgressiveComprehensionFemaleHumansLinguisticsMaleNeuropsychological TestsPilot ProjectsSpeechFrontotemporal lobar degenerationLogopenic PPANeurodegenerative diseasePrimary progressive aphasiaProgressive nonfluent aphasiatDCS

Identifiers

PMID27522537
PMCPMC5204261

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.