Evidence map›Paper›PMID 27522516›Full record

ArticleBreast cancer research and treatment2016

First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).

Christoph J Rageth, Elizabeth Am O'Flynn, Christopher Comstock, Claudia Kurtz, Rahel Kubik, Helmut Madjar, Domenico Lepori, Gert Kampmann, Alexander Mundinger, Astrid Baege and 6 more

Open access · hybridAbstract readConference ProceedingsConsensus Statement
In one paragraph

Article in Breast cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 263 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 4 countries.

Christoph J RagethBrust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland. c.rageth@brust-zentrum.ch.
Elizabeth Am O'FlynnInstitute of Cancer Research and Royal Marsden Hospital, London, UK.
Christopher ComstockMemorial Sloan Kettering Cancer Center, Breast and Imaging Center, 300 E 66th St Suite 723, New York, NY, 10065, USA.
Claudia KurtzInstitut für Radiologie und Nuklearmedizin, Luzerner Kantonsspital, 6000, Lucerne, Switzerland.
Rahel KubikInstitute of Radiology, Department of Medical Services, Kantonsspital Baden, im Ergel, 5404, Baden, Switzerland.
Helmut MadjarDKD HELIOS Klinik, Aukammallee 33, 65191, Wiesbaden, Germany.
Domenico LeporiImagerie du Flon, Vigie 5, 1000, Lausanne 20, Switzerland.
Gert KampmannCentro di Radiologia e Senologia Luganese, Corso Pestalozzi 3, 6900, Lugano, Switzerland.
Alexander MundingerMarienhospital Osnabrück, Bischofsstraße 1, 49074, Osnabrück, Germany.
Astrid BaegeBrust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
Thomas DeckerInstitut für Pathologie am Dietrich-Bonhoeffer-Klinikum, Salvador-Allende-Straße 30, 17036, Neubrandenburg, Germany.
Stefanie HoschBrust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
Christoph TauschBrust-Zentrum Zürich, Seefeldstr. 214, 8008, Zurich, Switzerland.
Jean-François DelaloyeCentre du sein, Centre Hospitalier, Universitaire Vaudois, 1011, Lausanne, Switzerland.
Elisabeth MorrisMemorial Sloan Kettering Cancer Center, Breast and Imaging Center, 300 E 66th St Suite 723, New York, NY, 10065, USA.
Zsuzsanna VargaInstitute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland.
Immunologie-Zentrum Zürich · CHMemorial Sloan Kettering Cancer Center · USCentre d'Imagerie BioMedicale · CHDietrich Bonhoeffer Klinikum · DEHelios Kliniken · DEHôpital Beau-Séjour · CHInstitute of Cancer Research · GBKantonsspital Baden · CHLuzerner Kantonsspital · CHMarienhospital Osnabrück · DEUniversity Hospital of Lausanne · CHUniversity Hospital of Zurich · CH

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The purpose of this study is to obtain a consensus for the therapy of B3 lesions. The first International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), classical lobular neoplasia (LN), papillary lesions (PL), benign phyllodes tumors (PT), and radial scars (RS) took place in January 2016 in Zurich, Switzerland organized by the International Breast Ultrasound School and the Swiss Minimally Invasive Breast Biopsy group-a subgroup of the Swiss Society of Senology. Consensus recommendations for the management and follow-up surveillance of these B3 lesions were developed and areas of research priorities were identified. The consensus recommendation for FEA, LN, PL, and RS diagnosed on core needle biopsy or vacuum-assisted biopsy (VAB) is to therapeutically excise the lesion seen on imaging by VAB and no longer by open surgery, with follow-up surveillance imaging for 5 years. The consensus recommendation for ADH and PT is, with some exceptions, therapeutic first-line open surgical excision. Minimally invasive management of selected B3 lesions with therapeutic VAB is acceptable as an alternative to first-line surgical excision.

Indexed as

Biopsy, Large-Core NeedleBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularDisease ManagementFemaleHumansImage-Guided BiopsyMammographyPhyllodes TumorPopulation SurveillancePractice Guidelines as TopicB3 lesionsBreastBreast surgeryConsensusUncertain malignant potentialVacuum-assisted biopsy

Identifiers

PMID27522516
PMCPMC5012144
OpenAlexW2517092382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.