ArticleCerebral cortex (New York, N.Y. : 1991)2016
Longitudinal Evidence for Dissociation of Anterior and Posterior MTL Resting-State Connectivity in Aging: Links to Perfusion and Memory.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- Adult lifespan effects on functional specialization along the hippocampal long axis.Frontiers in cognition · 2026Article
- Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.Scientific reports · 2025Article
- Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.Brain : a journal of neurology · 2025Article
- Article
- Somatomotor-visual resting state functional connectivity increases after 2 years in the UK Biobank longitudinal cohort.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Association of Cerebral Hypoperfusion and Poor Collaterals with Cognitive Impairment in Patients with Severe Vertebrobasilar Artery Stenosis.Journal of Alzheimer's disease reports · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea.Frontiers in neurology · 2023Article
- Disrupted Balance of Gray Matter Volume and Directed Functional Connectivity in Mild Cognitive Impairment and Alzheimer's Disease.Current Alzheimer research · 2023Article
- Time of day dependent longitudinal changes in resting-state fMRI.Frontiers in neurology · 2023Article
- Dopamine D1-signaling modulates maintenance of functional network segregation in aging.Aging brain · 2023Article
- Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Resting-state functional connectivity does not predict individual differences in the effects of emotion on memory.Scientific reports · 2022Article
- DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes: A new window into cognitive aging.Journal of neuroscience research · 2022Article
- Learning to forget: Hippocampal-amygdala connectivity partially mediates the effect of sexual trauma severity on verbal recall in older women undiagnosed with posttraumatic stress disorder.Journal of traumatic stress · 2022Article
- Medial Temporal Lobe Networks in Alzheimer's Disease: Structural and Molecular Vulnerabilities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function.Journal of Alzheimer's disease : JAD · 2022Article
- Longitudinal Changes in Hippocampal Network Connectivity in Alzheimer's Disease.Annals of neurology · 2021Article
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5 authors.
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Abstract
Neuroimaging studies of spontaneous signal fluctuations as measured by resting-state functional magnetic resonance imaging have revealed age-related alterations in the functional architecture of brain networks. One such network is located in the medial temporal lobe (MTL), showing structural and functional variations along the anterior-posterior axis. Past cross-sectional studies of MTL functional connectivity (FC) have yielded discrepant findings, likely reflecting the fact that specific MTL subregions are differentially affected in aging. Here, using longitudinal resting-state data from 198 participants, we investigated 5-year changes in FC of the anterior and posterior MTL. We found an opposite pattern, such that the degree of FC within the anterior MTL declined after age 60, whereas elevated FC within the posterior MTL was observed along with attenuated posterior MTL-cortical connectivity. A significant negative change-change relation was observed between episodic-memory decline and elevated FC in the posterior MTL. Additional analyses revealed age-related cerebral blood flow (CBF) increases in posterior MTL at the follow-up session, along with a positive relation of elevated FC and CBF, suggesting that elevated FC is a metabolically demanding alteration. Collectively, our findings indicate that elevated FC in posterior MTL along with increased local perfusion is a sign of brain aging that underlie episodic-memory decline.
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