ArticleCerebral cortex (New York, N.Y. : 1991)2017
Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The Caffeinated Brain Part 1: The Effects of Caffeine on Event-Related Potentials (ERPs)-A Systematic and Mechanistic Review.Nutrients · 2026Pooled it
- Biological Mechanisms of Sleep/Wake-Related Function.Biological psychiatry · 2025Review
- Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.Purinergic signalling · 2025Review
- Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice.Molecular psychiatry · 2024Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Adenosinergic Modulation of Layer 6 Microcircuitry in the Medial Prefrontal Cortex Is Specific to Presynaptic Cell Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Action of GABAThe journal of physiological sciences : JPS · 2024Article
- Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Delirium is associated with loss of feedback cortical connectivity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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- Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation.The journal of headache and pain · 2022Article
- Estradiol influences adenosinergic signaling and nonrapid eye movement sleep need in adult female rats.Sleep · 2022Article
- Dopamine Release in Nucleus Accumbens Is under Tonic Inhibition by Adenosine AThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cell-Type Specific Neuromodulation of Excitatory and Inhibitory NeuronsFrontiers in neural circuits · 2022Article
- Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice.Nature communications · 2021Article
- Decreased parenchymal arteriolar tone uncouples vessel-to-neuronal communication in a mouse model of vascular cognitive impairment.GeroScience · 2021Article
- Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.Current pharmaceutical design · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Adenosine is considered to be a key regulator of sleep homeostasis by promoting slow-wave sleep through inhibition of the brain's arousal centers. However, little is known about the effect of adenosine on neuronal network activity at the cellular level in the neocortex. Here, we show that adenosine differentially modulates synaptic transmission between different types of neurons in cortical layer 4 (L4) through activation of pre- and/or postsynaptically located adenosine A1 receptors. In recurrent excitatory connections between L4 spiny neurons, adenosine suppresses synaptic transmission through activation of both pre- and postsynaptic A1 receptors. In reciprocal excitatory and inhibitory connections between L4 spiny neurons and interneurons, adenosine strongly suppresses excitatory transmission via activating presynaptic A1 receptors but only slightly suppresses inhibitory transmission via activating postsynaptic A1 receptors. Adenosine has no effect on inhibitory transmission between L4 interneurons. The effect of adenosine is concentration dependent and first visible at a concentration of 1 μM. The effect of adenosine is blocked by the specific A1 receptor antagonist, 8-cyclopentyltheophylline or the nonspecific adenosine receptor antagonist, caffeine. By differentially affecting excitatory and inhibitory synaptic transmission, adenosine changes the excitation-inhibition balance and causes an overall shift to lower excitability in L4 primary somatosensory (barrel) cortical microcircuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.