ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Evaluating resolution requirements for subtle caenorhabditis elegans strain discrimination using classical descriptors and CNN-transformer models.Scientific reports · 2026Article
- Feeding performance, kinematics and skills change with age in a granivorous songbird.Proceedings. Biological sciences · 2025Article
- Modified tau leads to neuronal and global ribosome dysfunction inbioRxiv : the preprint server for biology · 2025Article
- Skateboarding's Olympic journey: do the performance profiles of top athletes remain consistent?Frontiers in physiology · 2025Article
- Aging in zebrafish is associated with reduced locomotor activity and strain dependent changes in bottom dwelling and thigmotaxis.PloS one · 2024Article
- Initial Severity of Injury Has Little Effect on the Temporal Profile of Long-Term Deficits in Locomotion, Anxiety, and Cognitive Function After Diffuse Traumatic Brain Injury.Neurotrauma reports · 2023Article
- A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.PLoS biology · 2022Article
- Water-Soluble Polysaccharides Extracted from Pueraria lobata Delay Aging of Caenorhabditis elegans under Heat Stress.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Article
- Metabolites and novel compounds with anti-microbial or antiaging activities from Cordyceps fumosorosea.AMB Express · 2022Article
- Evaluating ADHD Assessment for Dogs: A Replication Study.Animals : an open access journal from MDPI · 2022Article
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- An extract of Rosaceae, Solanaceae and Zingiberaceae increases health span and mobility in Caenorhabditis elegans.BMC nutrition · 2022Article
- MuscleAtlasExplorer: a web service for studying gene expression in human skeletal muscle.Database : the journal of biological databases and curation · 2020Article
- Healthspan pathway maps inAging · 2020Review
- Healthspan Enhancement by Olive Polyphenols inInternational journal of molecular sciences · 2020Article
- Optimized criteria for locomotion-based healthspan evaluation in C. elegans using the WorMotel system.PloS one · 2020Article
- Article
- An integrative modeling approach to the age-performance relationship in mammals at the cellular scale.Scientific reports · 2019Article
- The Performance Gap in Sport Can Help Determine Which Movements Were Most Essential to Human Evolution.Frontiers in physiology · 2019Article
- Deficits in Social Behavior Precede Cognitive Decline in Middle-Aged Mice.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Locomotion is one of the major physiological functions for most animals. Previous studies have described aging mechanisms linked to locomotor performance among different species. However, the precise dynamics of these age-related changes, and their interactions with development and senescence, are largely unknown. Here, we use the same conceptual framework to describe locomotor performances in Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. We show that locomotion is a consistent biomarker of age-related changes, with an asymmetrical pattern throughout life, regardless of the type of effort or its duration. However, there is variation (i) among species for the same mode of locomotion, (ii) within species for different modes of locomotion, and (iii) among individuals of the same species for the same mode of locomotion. Age-related patterns are modulated by genetic (such as selective breeding) as well as environmental conditions (such as temperature). However, in all cases, the intersection of the rising developmental phase and the declining senescent phase reveals neither a sharp transition nor a plateau, but a smooth transition, emphasizing a crucial moment: the age at peak performance. This transition may define a specific target for future investigations on the dynamics of such biological interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.