ArticleRevista brasileira de hematologia e hemoterapia
Assessment of blood sample stability for complete blood count using the Sysmex XN-9000 and Mindray BC-6800 analyzers.
Article in Revista brasileira de hematologia e hemoterapia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- How Long can we Store Blood Samples: A Systematic Review and Meta-Analysis.EBioMedicine · 2017Pooled it
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- Red blood cell distribution width as a biomarker: the importance of age-dependent changes and other variables.Aging clinical and experimental research · 2023Article
- Author response to comment on: Hematological parameters and early-onset coronary artery disease: a retrospective case-control study based on 3366 participants.Therapeutic advances in chronic disease · 2023Article
- Clinical assessment of neutrophil gelatinase-associated lipocalin as a potential diagnostic marker for neonatal sepsis: a prospective cohort study.Annals of medicine · 2022Article
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- Analyte stability, instrumentation, and the red blood cell distribution width: comments on "Red blood cell distribution width and tumor necrosis factor‑α for the early prediction of coronary artery lesion in Kawasaki disease: a retrospective study". Eur J Pediatr. 2021 Sep 7.doi: 10.1007/s00431-021-04,252-3.European journal of pediatrics · 2022Article
- Stability of hematological analytes during 48 hours storage at three temperatures using Cell-Dyn hematology analyzer.Journal of medical biochemistry · 2021Article
- FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors.Vox sanguinis · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent hematological analyzers have different analytical performances that are often reflected in the criteria for sample stability of the complete blood count. This study aimed to assess the stability of several hematological parameters using the XN-9000 Sysmex and BC-6800 Mindray analyzers.
methodsThe impact of storage at room temperature and 4°C was evaluated after 2, 4, 6, 8, 24, 36 and 48h using ten normal and 40 abnormal blood samples. The variation from the baseline measurement was evaluated by the Steel-Dwass-Critchlow-Fligner test and by Bland-Altman plots, using quality specifications and critical difference as the total allowable variation.
resultsRed blood cells and reticulocyte parameters (i.e. hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, red blood cell distribution width, immature reticulocyte fractions, low-fluorescence reticulocytes, middle-fluorescence reticulocytes, high fluorescence mononuclear cells) showed less stability compared to leukocyte and platelet parameters (except for monocyte count and mean platelet volume). The bias for hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration and red blood cell distribution width coefficient of variation was higher than the critical difference after 8h using both analyzers.
conclusionBlood samples measured with both analyzers do not show analytically significant changes in up to 2h of storage at room temperature and 4°C. However, the maximum time for analysis can be extended for up to 8h when the bias is compared to the critical difference.
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