Evidence map›Paper›PMID 27521844›Full record

ArticleCephalalgia : an international journal of headache2017

Reduced insula habituation associated with amplification of trigeminal brainstem input in migraine.

Jeungchan Lee, Richard L Lin, Ronald G Garcia, Jieun Kim, Hyungjun Kim, Marco L Loggia, Ishtiaq Mawla, Ajay D Wasan, Robert R Edwards, Bruce R Rosen and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cephalalgia : an international journal of headache, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

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  11. The fifth cranial nerve in headaches.The journal of headache and pain · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Jeungchan Lee1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Richard L Lin1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ronald G Garcia1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jieun Kim5 Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
Hyungjun Kim5 Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea.
Marco L Loggia1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ishtiaq Mawla1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ajay D Wasan6 Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Robert R Edwards7 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bruce R Rosen1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nouchine Hadjikhani1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Vitaly Napadow1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USKorea Institute of Oriental Medicine · KRMassachusetts General Hospital · USBrigham and Women's Hospital · USFundación Cardiovascular de Colombia · COUniversity of Pittsburgh Medical Center · US

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0M
Brain Mechanisms Underlying CBT-Related Reductions in FibromyalgiaR01AR064367 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R, NAPADOW, VITALY · 2014 to 2018
$4.0M
Neuroimaging Approaches to Deconstructing Acupuncuture for Chronic PainR01AT007550 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, RICHARD E, NAPADOW, VITALY · 2013 to 2019
$3.4M
Neural-Physiology Biosignature Shared across Negative Valence and Arousal DomainsR21MH103468 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, NAPADOW, VITALY · 2014 to 2015
$482k
The Role of Neuroimmune Activation in Chronic Pain and Negative AffectR21NS087472 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2014 to 2015
$479k
PET-MR Investigation of Microglial Activation in MigraineR21NS082926 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HADJIKHANI, NOUCHINE · 2014 to 2015
$475k
NCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT007550NCRR NIH HHS P41 RR014075NIAMS NIH HHS R01 AR064367NIMH NIH HHS R21 MH103468NINDS NIH HHS R21 NS082926NINDS NIH HHS R21 NS087472
6 · The paper itself

Abstract

Background Impaired sensory processing in migraine can reflect diminished habituation, increased activation, or even increased gain or amplification of activity from the primary synapse in the brainstem to higher cortical/subcortical brain regions. Methods We scanned 16 episodic migraine (interictal) and 16 healthy controls (cross-sectional study), and evaluated brain response to innocuous air-puff stimulation over the right forehead in the ophthalmic nerve (V

Indexed as

AdultBrain StemCerebral CortexCross-Sectional StudiesEvoked Potentials, SomatosensoryFemaleHabituation, PsychophysiologicHumansMaleMiddle AgedMigraine DisordersTrigeminal NerveamplificationhabituationMigraineposterior insula cortexspinal trigeminal nucleus

Identifiers

PMID27521844
PMCPMC9176411
OpenAlexW2512931860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.