ArticleMolecular and cellular neurosciences2016
Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity.
Open access · greenAbstract read
In one paragraph
Article in Molecular and cellular neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1.JCI insight · 2025Article
- Pharmacokinetics and Pharmacodynamics of Levetiracetam in Neonatal Seizures: What We Still Need to Know.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- "Catch me if you can" - locating the "Black Sheep" neurons after early-life seizures.Acta epileptologica · 2024Article
- Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.Brain : a journal of neurology · 2024Article
- Calcium-permeable AMPA and kainate receptors of GABAergic neurons.Biophysical reviews · 2024Review
- Anti-seizure medication-induced developmental cell death in neonatal rats is unaltered by history of hypoxia.Epilepsy research · 2024Article
- Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures.The Journal of clinical investigation · 2024Article
- Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives.International journal of molecular sciences · 2023Article
- Febrile Seizures Cause a Rapid Depletion of Calcium-Permeable AMPA Receptors at the Synapses of Principal Neurons in the Entorhinal Cortex and Hippocampus of the Rat.International journal of molecular sciences · 2023Article
- KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.Cell death and differentiation · 2023Article
- In the fast lane: Receptor trafficking during status epilepticus.Epilepsia open · 2023Review
- Increased glutamatergic synaptic transmission during development in layer II/III mouse motor cortex pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Quadripulse transcranial magnetic stimulation inducing long-term depression in healthy subjects may increase seizure risk in some patients with intractable epilepsy.Clinical neurophysiology practice · 2023Article
- Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats.Frontiers in neurology · 2023Article
- Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.International journal of molecular sciences · 2022Article
- Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid.British journal of pharmacology · 2022Article
- The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy.Frontiers in molecular neuroscience · 2022Review
- Maternal Hypoxia Increases the Excitability of Neurons in the Entorhinal Cortex and Dorsal Hippocampus of Rat Offspring.Frontiers in neuroscience · 2022Article
- Insertion of Calcium-Permeable AMPA Receptors during Epileptiform Activity In Vitro Modulates Excitability of Principal Neurons in the Rat Entorhinal Cortex.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Jocelyn J Lippman-BellPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Boston Children's Hospital, Boston, MA 02114, United States; Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, United States.
Chengwen ZhouBoston Children's Hospital, Boston, MA 02114, United States.
Hongyu SunPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Boston Children's Hospital, Boston, MA 02114, United States.
Joel S FeskeBoston Children's Hospital, Boston, MA 02114, United States.
Frances E JensenPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Boston Children's Hospital, Boston, MA 02114, United States. Electronic address: frances.jensen@uphs.upenn.edu.
Boston Children's Hospital · USUniversity of Pennsylvania · USPhiladelphia College of Osteopathic Medicine · US
Funding
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MUnderstanding the Cognitive Impact of Early Life EpilepsyDP1OD003347 · OD · UNIVERSITY OF PENNSYLVANIA · PI JENSEN, FRANCES E · 2007 to 2011
$4.2MThe Epileptogenic Effect of Perinatal HypoxiaR01NS031718 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI JENSEN, FRANCES E · 1997 to 2011
$3.8MEarly Life Seizures Disrupt Critical Period PlasticityR01NS080565 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HENSCH, TAKAO K, JENSEN, FRANCES E · 2013 to 2016
$1.8MThe Epileptogenic Effect of Perinatal HypoxiaR56NS031718 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI JENSEN, FRANCES E · 2007 to 2013
$907kCalcium signaling as a convergence point of epilepsy and cognitive dysfunctionF32NS068161 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI LIPPMAN-BELL, JOCELYN J · 2010 to 2011
$100kNICHD NIH HHS P30 HD018655NIH HHS DP1 OD003347NINDS NIH HHS F32 NS068161NINDS NIH HHS R01 NS031718NINDS NIH HHS R01 NS080565NINDS NIH HHS R56 NS031718
Abstract
Calcium (Ca
Indexed as
Calcium SignalingLong-Term PotentiationAnimalsCA1 Region, HippocampalMaleRatsRats, Long-EvansReceptors, AMPASeizuresSynapsesReceptors, AMPAEpilepsyGlutamate receptorNeonateSynaptic plasticity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.