ArticleJournal of immunology (Baltimore, Md. : 1950)2016
A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies.Scientific reports · 2022Article
- Blood leukocyte composition and function in periparturient ewes kept on different dietary magnesium supply.BMC veterinary research · 2020Article
- Transcriptomic Analysis of Rat Macrophages.Frontiers in immunology · 2020Article
- Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.Frontiers in immunology · 2020Article
- Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of theJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Article
- Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves.Frontiers in cardiovascular medicine · 2018Article
- The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Expression of Csf1r in adults is restricted to cells of the macrophage lineage. Transgenic reporters based upon the Csf1r locus require inclusion of the highly conserved Fms-intronic regulatory element for expression. We have created Csf1r-EGFP transgenic sheep via lentiviral transgenesis of a construct containing elements of the mouse Fms-intronic regulatory element and Csf1r promoter. Committed bone marrow macrophage precursors and blood monocytes express EGFP in these animals. Sheep monocytes were divided into three populations, similar to classical, intermediate, and nonclassical monocytes in humans, based upon CD14 and CD16 expression. All expressed EGFP, with increased levels in the nonclassical subset. Because Csf1r expression coincides with the earliest commitment to the macrophage lineage, Csf1r-EGFP bone marrow provides a tool for studying the earliest events in myelopoiesis using the sheep as a model.
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Registered trials
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