ArticleJournal of immunology (Baltimore, Md. : 1950)2016
NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- The development of innate lymphoid cells.Nature immunology · 2026Review
- Lung NK cells are sufficient to control viral dissemination during respiratory MCMV infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells.The Journal of experimental medicine · 2025Article
- NK cells restrain cytotoxic CD8Science immunology · 2024Article
- Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation.Immunological reviews · 2024Review
- Tissue-resident memory NK cells: Homing in on local effectors and regulators.Immunological reviews · 2024Review
- No time to die: Epigenetic regulation of natural killer cell survival.Immunological reviews · 2024Review
- Genetic distinction between functional tissue-resident and conventional natural killer cells.iScience · 2023Article
- Article
- Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathologyFrontiers in medicine · 2022Article
- ILC Differentiation from Progenitors in the Bone Marrow.Advances in experimental medicine and biology · 2022Review
- Article
- Natural killers or ILC1s? That is the question.Current opinion in immunology · 2021Review
- Transcriptional Regulation of Mouse Tissue-Resident Natural Killer Cell Development.Frontiers in immunology · 2020Review
- Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.Annual review of cell and developmental biology · 2019Review
- True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity.Trends in immunology · 2019Review
- Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses.Journal of virology · 2019Article
- Innate lymphocytes-lineage, localization and timing of differentiation.Cellular & molecular immunology · 2019Review
- Transcriptional and Functional Programming of Decidual Innate Lymphoid Cells.Frontiers in immunology · 2019Article
- Dazed and Confused: NK Cells.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The submandibular salivary gland (SMG), a major site of persistent infection for many viruses, contains a large NK cell population. Using NFIL3-deficient mice, PLZF reporter/fate mapping mice, and mixed bone marrow chimeras, we identified two distinct populations of NK cells in the SMG. Although phenotypically unique, the main population relies on NFIL3, but not PLZF, for development and, therefore, is developmentally similar to the conventional NK cell subset. In contrast, we found that approximately one quarter of the SMG NK cells develop independently of NFIL3. Interestingly, NFIL3-independent SMG tissue-resident NK (trNK) cells are developmentally distinct from liver trNK cells. We also demonstrated that the SMG NK cell hyporesponsive phenotype during murine CMV infection is tissue specific and not cell intrinsic. In contrast, NFIL3-independent SMG trNK cells are intrinsically hyporesponsive. Altogether, our data show that the SMG tissue environment shapes a unique repertoire of NK-like cells with distinct phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.