Evidence map›Paper›PMID 27521262›Full record

ArticleFEMS microbiology letters2016

Epigenetics knocks on synthetic biology's door.

Zuemy Rodriguez-Escamilla, Mario A Martínez-Núñez, Enrique Merino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEMS microbiology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zuemy Rodriguez-EscamillaDepartamento de Microbiología Molecular, Instituto de Biotecnología, UNAM. Av. Universidad 2001, Cuernavaca, Morelos CP 62210, México.
Mario A Martínez-NúñezLaboratorio de Ecogenómica. Unidad Académica de Ciencias y Tecnología de Yucatán. Facultad de Ciencias, UNAM. Sierra Papacal-Chuburna Km 5. Mérida, Yucatán CP 97302, México.
Enrique MerinoDepartamento de Microbiología Molecular, Instituto de Biotecnología, UNAM. Av. Universidad 2001, Cuernavaca, Morelos CP 62210, México merino@ibt.unam.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetics is the study of heritable changes in gene expression without concomitant changes in DNA sequence. Due to its relevance in development, differentiation and human health, epigenetics has recently become an emerging area of science with regard to eukaryotic organisms and has shown enormous potential in synthetic biology. However, significant examples of epigenetic regulation in bacterial synthetic biology have not yet been reported. In the current study, we present the first model of such an epigenetic circuit. We termed the circuit the alternator circuit because parental cells carrying this circuit and their progeny alternate between distinct and heritable cellular fates without undergoing changes in genome sequence. Furthermore, we demonstrated that the alternator circuit exhibits hysteresis because its output depends not only on its present state but also on its previous states.

Indexed as

Epigenesis, GeneticSynthetic BiologyBacteriophage T7DNA-Directed RNA PolymerasesDNA MethylationEscherichia coliHumansSigma FactorDNA-Directed RNA PolymerasesRNA polymerase sigma 70Sigma Factorepigenetic circuitsExcludonheritable cellular fateshysteresisSigma 70T7 RNA polymerase

Identifiers

PMID27521262
PMCPMC5012592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.