Evidence map›Paper›PMID 27521214›Full record

SynthesisOncotarget2016

Quantitative assessment of CD44 genetic variants and cancer susceptibility in Asians: a meta-analysis.

Vishal Chandra, Yun-Mi Lee, Usha Gupta, Balraj Mittal, Jong Joo Kim, Rajani Rai

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. The mechanism of ncRNA in trastuzumab resistance in HER2-positive tumors.Medical oncology (Northwood, London, England) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Vishal ChandraDepartment of Biosciences, Integral University, Lucknow, UP, India.
Yun-Mi LeeSchool of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
Usha GuptaSanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Balraj MittalSanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Jong Joo KimSchool of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
Rajani RaiSchool of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
Yeungnam University · KRSanjay Gandhi Post Graduate Institute of Medical Sciences · INIntegral University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD44 is a well-established cancer stem cell marker playing a crucial role in tumor metastasis, recurrence and chemo-resistance. Genetic variants of CD44 have been shown to be associated with susceptibility to various cancers; however, the results are confounding. Hence, we performed a meta-analysis to clarify these associations more accurately. Overall, rs13347 (T vs. C: OR=1.30, p=<0.004, pcorr=0.032; CT vs. CC: OR=1.29, p=0.015, pcorr=0.047; TT vs. CC: OR=1.77, p=<0.000, pcorr=0.018; CT+TT vs. CC: OR=1.34, p=<0.009, pcorr=0.041) and rs187115 (GG vs. AA: OR=2.34, p=<0.000, pcorr=0.025; AG vs. AA: OR=1.59, p=<0.000, pcorr=0.038; G vs. A allele OR=1.56, p=0.000, pcorr=0.05; AG+GG vs. AA: OR=1.63, p=<0.000, pcorr=0.013) polymorphisms were found to significantly increase the cancer risk in Asians. On the other hand, rs11821102 was found to confer low risk (A vs. G: OR=0.87, p=<0.027, pcorr=0.04; AG vs. GG: OR=0.85, p=<0.017, pcorr=0.01; AG+AA vs. GG: OR=0.86, p=<0.020, pcorr=0.02). Based on our analysis, we suggest significant role of CD44 variants (rs13347, rs187115 and rs11821102) in modulating individual's cancer susceptibility in Asians. Therefore, these variants may be used as predictive genetic biomarkers for cancer predisposition in Asian populations. However, more comprehensive studies involving other cancers and/or populations, haplotypes, gene-gene and gene-environment interactions are necessary to delineate the role of these variants in conferring cancer risk.

Indexed as

Asian PeopleGenetic Predisposition to DiseaseGenetic VariationHumansHyaluronan ReceptorsNeoplasmsPolymorphism, GeneticPolymorphism, Single NucleotideRisk FactorsCD44 protein, humanHyaluronan ReceptorscancerCD44meta-analysissingle nucleotide polymorphisms (SNP)susceptibility

Identifiers

PMID27521214
PMCPMC5342053
OpenAlexW2515593487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.