ArticleOphthalmology2016
Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography.
Article in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Detection of intracranial hypertension in children using optical coherence tomography: a systematic review.BMJ open · 2021Pooled it
- Normative data for optical coherence tomography in children: a systematic review.Eye (London, England) · 2021Pooled it
- Pooled it
- Feasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.Eye (London, England) · 2026Article
- Age-Related Differences in Optical Coherence Tomography and Optical Coherence Tomography Angiography Parameters Between Healthy Children and Adults: A Comparative Analysis in a Caucasian Population.Journal of personalized medicine · 2025Article
- Is the presence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children related to the optic disc area, scleral canal diameter and refractive status?Eye (London, England) · 2025Article
- Optic disc changes in patients less than 3 years of age with congenital cataract.International journal of ophthalmology · 2025Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- Comparing the morphology of optic nerve head and lamina cribrosa in full-term and preterm school-aged children.Eye (London, England) · 2024Article
- Characteristics of the Peripapillary Structure and Vasculature in Patients With Myopic Anisometropia.Translational vision science & technology · 2023Article
- Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022Review
- Longitudinal Evaluation of Changes in Retinal Architecture Using Optical Coherence Tomography in Achromatopsia.Investigative ophthalmology & visual science · 2022Article
- Handheld optical coherence tomography removes barriers to imaging the eyes of young children.Eye (London, England) · 2022Article
- Segmentation of the foveal and parafoveal retinal architecture using handheld spectral-domain optical coherence tomography in children with Down syndrome.Eye (London, England) · 2022Article
- Article
- Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis.Translational vision science & technology · 2021Article
- Anterior Chamber Measurements in Healthy Children: A Cross-Sectional Study Using Optical Coherence Tomography.Translational vision science & technology · 2021Article
- Optic Nerve Head and Retinal Abnormalities Associated with Congenital Fibrosis of the Extraocular Muscles.International journal of molecular sciences · 2021Article
- Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.American journal of ophthalmology · 2021Observational
- Enhanced neuro-ophthalmologic evaluation to support separation of craniopagus twins.Journal of surgical case reports · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT).
designProspective cross-sectional study.
participantsThree hundred fifty-two children aged between 1 day and 13 years.
methodsAll participants were imaged using handheld SD OCT without sedation during a single scan session. The percentage of successful scans was calculated. Interexaminer reproducibility and differences between right and left eyes were assessed using intraclass correlation coefficients (ICCs). Images were analyzed using ImageJ software. The developmental trajectories over time for ONH parameters were calculated using fractional polynomial modelling.
main outcome measuresDisc and cup diameter (expressed as distance in micrometers and visual angle in degrees), cup depth, Bruch's membrane opening-minimum rim width (BMO-MRW), retinal thickness, and retinal nerve fiber layer (RNFL; 1700 μm and 6° from the disc center).
resultsOn average, 70% of participants were imaged successfully. Interexaminer reliability was excellent (ICC, >0.89) for diametric and retinal thickness parameters. Right and left eyes were similar for diametric measurements (ICC, >0.79), but more variable for nasal BMO-MRW, RNFL, and retinal thickness. The mean disc and cup diameter increase by 30% and 40%, respectively, between birth and 13 years of age when expressed as a distance measure, but remained constant (at 5°-5.5° and 2°, respectively) when expressed as a visual angle with reference to the eye nodal point. The peripapillary temporal RNFL demonstrated a marked initial decrease of nearly 35% between birth and approximately 18 months of age. This was followed by a slow increase up to 12 years of age when measured at 1700 μm from the disc center, although there was little change when measured at 6° from the disc center.
conclusionsWe demonstrated feasibility of handheld SD OCT imaging of the ONH in full-term infants and children without anaesthesia or sedation. This is the first in vivo handheld SD OCT study to describe the development of ONH parameters during the critical early years of visual maturation. Our results provide a normative database for use in routine practice and further studies of ONH pathologic features.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.