ArticleApplied and environmental microbiology2016
Antimicrobial and Virulence-Modulating Effects of Clove Essential Oil on the Foodborne Pathogen Campylobacter jejuni.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Current State of Knowledge Regarding WHO High Priority Pathogens-Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil-Ciprofloxacin Combination.Veterinary medicine and science · 2026Article
- Environment-Responsive Sustained-Release Nanoparticles for the Protection, Delivery and Release of Clove Essential Oil to Improve Foodborne Bacterial Colitis Treatment.Advanced healthcare materials · 2026Article
- Factors Influencing Biofilm Formation ofFoods (Basel, Switzerland) · 2026Article
- Syzygium aromaticum L. (Clove): A Comprehensive Reveiw of Its Ethnopharmacological Uses and Pharmacological Activities.Chinese journal of integrative medicine · 2026Review
- A Review of Essential Oils with Anti-Foods (Basel, Switzerland) · 2026Review
- Essential Oils as Antimicrobial Agents Against WHO Priority Bacterial Pathogens: A Strategic Review of In Vitro Clinical Efficacy, Innovations and Research Gaps.Antibiotics (Basel, Switzerland) · 2025Review
- Effect of Temperature, Surface, and Medium Qualities on the Biofilm Formation ofFoods (Basel, Switzerland) · 2025Article
- Article
- Harnessing medicinal plant compounds for the control of Campylobacter in foods: a comprehensive review.Veterinary research communications · 2024Review
- Antimicrobial Activity againstPolymers · 2024Article
- Effect of low concentrations of lactic acid and temperature on the expression of adhesion, invasion, and toxin-encoding genes ofIranian journal of microbiology · 2024Article
- Phytogenics in Ginger,Animals : an open access journal from MDPI · 2023Review
- Potential of Essential Oils in the Control ofMicroorganisms · 2023Review
- Ability of Garlic and Ginger Oil to ReduceAnimals : an open access journal from MDPI · 2022Article
- Recent advances in nutritional composition, phytochemistry, bioactive, and potential applications ofFrontiers in nutrition · 2022Review
- Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis-Results from a Preclinical Murine Intervention Study.Microorganisms · 2021Article
- Antimicrobial Effect and the Mechanism of Diallyl Trisulfide againstAntibiotics (Basel, Switzerland) · 2021Article
- An Overview of the Potential Therapeutic Applications of Essential Oils.Molecules (Basel, Switzerland) · 2021Review
- Select Phytochemicals ReduceFrontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our study investigated the antimicrobial action of clove (Syzygium aromaticum) essential oil (EO) on the zoonotic pathogen Campylobacter jejuni After confirming the clove essential oil's general antibacterial effect, we analyzed the reference strain Campylobacter jejuni NCTC 11168. Phenotypic, proteomic, and transcriptomic methods were used to reveal changes in cell morphology and functions when exposed to sublethal concentrations of clove EO. The normally curved cells showed markedly straightened and shrunken morphology on the scanning electron micrographs as a result of stress. Although, oxidative stress, as a generally accepted response to essential oils, was also present, the dominance of a general stress response was demonstrated by reverse transcription-PCR (RT-PCR). The results of RT-PCR and two-dimensional (2D) PAGE revealed that clove oil perturbs the expression of virulence-associated genes taking part in the synthesis of flagella, PEB1, PEB4, lipopolysaccharide (LPS), and serine protease. Loss of motility was also detected by a phenotypic test. Bioautographic analysis revealed that besides its major component, eugenol, at least four other spots of clove EO possessed bactericidal activity against C. jejuni Our findings show that clove EO has a marked antibacterial and potential virulence-modulating effect on C. jejuni IMPORTANCE: This study demonstrates that the components of clove essential oil influence not only the expression of general stress genes but also the expression of virulence-associated genes. Based on this finding, alternative strategies can be worked on to control this important foodborne pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.