Evidence map›Paper›PMID 27520797›Full record

ArticleRheumatology (Oxford, England)2016

Cancer risk in cutaneous lupus erythematosus: a population-based cohort study.

Abha G Singh, Cynthia S Crowson, Siddharth Singh, Mark Denis P Davis, Hilal Maradit-Kremers, Eric L Matteson, Vaidehi R Chowdhary

Open access · bronzeAbstract read
In one paragraph

Article in Rheumatology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 27 citations in OpenAlex.

  1. Incidence of cutaneous lupus erythematosus and systemic progression: A Nationwide study in Korea.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  2. Article
  3. Article
  4. Malignancy in Systemic Lupus Erythematosus (SLE) PatientsAsian Pacific journal of cancer prevention : APJCP · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Abha G SinghDivision of Rheumatology, Mayo Clinic, Rochester, MN.
Cynthia S CrowsonDivision of Rheumatology, Mayo Clinic, Rochester, MN.
Siddharth SinghDivision of Biomedical Informatics, University of California San Diego, La Jolla, CA.
Mark Denis P DavisDepartment of Dermatology, Mayo Clinic, Rochester, MN, USA.
Hilal Maradit-KremersDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Eric L MattesonDivision of Rheumatology, Mayo Clinic, Rochester, MN.
Vaidehi R ChowdharyDivision of Rheumatology, Mayo Clinic, Rochester, MN chowdhary.vaidehi@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USUniversity of California, San Diego · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NCATS NIH HHS UL1 TR000135NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

objectiveImmune dysregulation associated with chronic autoimmune diseases, such as SLE, has been associated with increased cancer risk. It is unclear whether isolated cutaneous lupus erythematosus (CLE) modifies cancer risk. We estimated the cumulative incidence of cancer in a population-based CLE cohort and compared the risk with a matched non-CLE cohort.

methodsAll incident cases of CLE in Olmsted County, MN, USA between 1965 and 2005 were identified and followed to December 2013. Estimates for the cumulative incidence of any cancer and skin cancer in patients with CLE were derived and compared with an age-, sex- and calendar-year-matched non-CLE cohort using Cox models.

resultsThere were a total of 155 patients with CLE [age at diagnosis, 48 (sd 16) years; 65% females; BMI, 26.3 (sd 7.1) kg/m

conclusionCLE is not associated with an increased risk of any cancers, including skin cancers, compared with the general population. However, the number of events was small, limiting the power of the study.

Indexed as

Cohort StudiesEarly Detection of CancerFemaleHumansIncidenceLupus Erythematosus, CutaneousMaleMiddle AgedMinnesotaNeoplasmsRisk Factorscancercutaneous lupusincidenceinflammationmelanoma

Identifiers

PMID27520797
PMCPMC5731492
OpenAlexW2512745735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.