ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2017
Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- Adjunctive Cilostazol Therapy for Sinus Node Dysfunction After Heart Transplantation.JACC. Case reports · 2026Article
- Amiodarone use prior to cardiac transplant in children is associated with increased need for post-transplant chronotropic support.JHLT open · 2026Article
- Article
- Optimization of pretransplant amiodarone therapy to prevent primary graft dysfunction following heart transplantation.JHLT open · 2025Article
- Primary graft dysfunction in heart transplantation: the challenge to survival.Journal of cardiothoracic surgery · 2024Review
- Design and characteristics of the prophylactic intra-operative ventricular arrhythmia ablation in high-risk LVAD candidates (PIVATAL) trial.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- Amiodarone Use and All-Cause Mortality in Patients With a Continuous-Flow Left Ventricular Assist Device.Journal of the American Heart Association · 2022Article
- The Interaction of Amiodarone and Continuous-flow Left Ventricular Assist Device Use in Risk of Severe Primary Graft Dysfunction Following Heart Transplantation.Transplantation direct · 2022Article
- Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.Cardiovascular drugs and therapy · 2021Article
- Acute amiodarone pulmonary toxicity in the form of organizing pneumonia triggered by orthotopic heart transplantation.Respiratory medicine case reports · 2021Article
- Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post-transplant mortality.ESC heart failure · 2020Article
- Discontinuing amiodarone treatment prior to heart transplantation lowers incidence of severe primary graft dysfunction.Clinical transplantation · 2020Article
- Continuous-flow mechanical circulatory support is not associated with early graft failure: An analysis of the International Society for Heart and Lung Transplantation registry.Clinical transplantation · 2019Article
- Re-Thinking Re-Synching in Left Ventricular Assist Device Recipients.Journal of the American Heart Association · 2018Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPre-transplant amiodarone use has been postulated as a risk factor for morbidity and mortality after orthotopic heart transplantation (OHT). We assessed pre-OHT amiodarone use and tested the hypothesis that it is associated with impaired post-OHT outcomes.
methodsWe performed a retrospective cohort analysis of adult OHT recipients from the registry of the International Society for Heart and Lung Transplantation (ISHLT). All patients had been transplanted between 2005 and 2013 and were stratified by pre-OHT amiodarone use. We derived propensity scores using logistic regression with amiodarone use as the dependent variable, and assessed the associations between amiodarone use and outcomes with Kaplan-Meier analysis after matching patients 1:1 based on propensity score, and with Cox regression with adjustment for propensity score.
resultsOf the 14,944 OHT patients in the study cohort, 32% (N = 4,752) received pre-OHT amiodarone. Amiodarone use was higher in recent years (29% in 2005 to 2007, 32% in 2008 to 2010, 35% in 2011 to 2013). Amiodarone-treated patients were older and more frequently had a history of sudden cardiac death (27% vs 13%) and pre-OHT mechanical circulatory support. Key donor characteristics and allograft ischemia times were similar between groups. In propensity-matched analyses, amiodarone-treated patients had higher rates of cardiac reoperation (15% vs 13%) and permanent pacemaker (5% vs 3%) after OHT and before discharge. Amiodarone-treated patients also had higher 1-year mortality (hazard ratio 1.15, 95% confidence interval 1.02 to 1.30), but the risks of early graft failure, retransplantation and rehospitalization were similar between groups.
conclusionsAmiodarone use before OHT was independently associated with increased 1-year mortality. The need for amiodarone therapy should be carefully and continuously assessed in patients awaiting OHT.
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