Evidence map›Paper›PMID 27520739›Full record

ArticleInternational orthopaedics2016

Comparative study suggests that human bone morphogenetic proteins have no influence on the outcome of operative treatment of aseptic clavicle non-unions.

Christian von Rüden, Mario Morgenstern, Jan Friederichs, Peter Augat, Simon Hackl, Alexander Woltmann, Volker Bühren, Christian Hierholzer

Open access · hybridAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Bone morphogenetic proteins in fracture repair.International orthopaedics · 2018
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Christian von RüdenDepartment of Trauma Surgery, Trauma Centre Murnau, Professor Küntscher Str. 8, 82418, Murnau, Germany. christian.vonrueden@bgu-murnau.de.
Mario MorgensternDepartment of Traumatology, University Hospital Basel, Basel, Switzerland.
Jan FriederichsDepartment of Trauma Surgery, Trauma Centre Murnau, Professor Küntscher Str. 8, 82418, Murnau, Germany.
Peter AugatInstitute of Biomechanics, Paracelsus Medical University, Salzburg, Austria.
Simon HacklDepartment of Trauma Surgery, Trauma Centre Murnau, Professor Küntscher Str. 8, 82418, Murnau, Germany.
Alexander WoltmannDepartment of Trauma Surgery, Trauma Centre Murnau, Professor Küntscher Str. 8, 82418, Murnau, Germany.
Volker BührenDepartment of Trauma Surgery, Trauma Centre Murnau, Professor Küntscher Str. 8, 82418, Murnau, Germany.
Christian HierholzerDepartment of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland.
Berufsgenossenschaftliche Unfallklinik Murnau · DEParacelsus Medical University · ATUniversity Hospital of Basel · CHUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate the clinical and radiological outcome following compression plate fixation in combination with autologous bone grafting, with and without additional application of recombinant human bone morphogenetic protein (rhBMP) for treatment of aseptic clavicle non-union.

methodsBetween April 2004 and April 2015, 82 patients were treated for clavicle fracture and had developed aseptic clavicle non-union. Seventy-three out of 82 patients were available for follow-up at least one year after revision surgery; among them, 27 women and 46 men, with a median age of 49 (range, 19-86) years. Forty-five patients received compression plate osteosynthesis with autologous bone grafting, and 28 patients obtained compression plate fixation with autologous bone grafting and additional application of rhBMP-2 (3/28 patients) or rhBMP-7 (25/28 patients).

resultsSeventy out of 73 non-unions (96 %) healed within 12 months after revision surgery. Functional outcome according to the DASH Outcome Measure (with rhBMP, 33.16 ± 1.17 points; without rhBMP, 30.58 ± 2.12 points [mean ± SEM]; p = 0.81), non-union healing (p = 0.86), time interval between revision surgery and bone healing (p = 0.37), as well as post-operative complications, did not demonstrate relevant differences between the treatment groups and were not age-dependent. DISCUSSION: Functional and radiological results demonstrate that successful healing of aseptic clavicle non-union is dependent on radical resection of non-union tissue, restoration of length of the shoulder girdle and application of stable locking-plate osteosynthesis in combination with autologous bone grafting, but not dependent on application of additional rhBMP.

Indexed as

Administration, TopicalAdultAgedAged, 80 and overBone Morphogenetic Protein 2Bone Morphogenetic Protein 7Bone PlatesBone TransplantationClavicleFemaleFracture Fixation, InternalFracture HealingFractures, UnunitedHumansMaleMiddle AgedBMP7 protein, humanBone Morphogenetic Protein 2Bone Morphogenetic Protein 7recombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaBone graftBone morphogenetic proteinClavicleDASH Outcome MeasureLocking compression plateNon-unionrhBMP-2rhBMP-7

Identifiers

PMID27520739
OpenAlexW2507987914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.