ArticleMolecular and cellular biochemistry2004
Structure and regulation of human troponin genes.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- HIC2 regulates isoform switching during maturation of the cardiovascular system.Journal of molecular and cellular cardiology · 2018Article
- Transcriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa.Scientific reports · 2016Article
- The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.The Journal of biological chemistry · 2012Article
- A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Comparative transcriptional and biochemical studies in muscle of myotonic dystrophies (DM1 and DM2).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2009Article
- Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy.Progress in molecular and subcellular biology · 2006Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent completion of a first draft of the human genome has allowed "in silico" genome browsing to become routine. Such computer-based research is now a useful adjunct to experiments based at the bench, and is accelerating gene discovery and the analysis and understanding of genes in their genomic contexts. This review summarises recent findings on genes encoding proteins of the troponin complex. We describe the organization of the three pairs of genes which encode isoforms of troponins I and T, and discuss how this relates to their evolution and regulation. Detailed analysis of the chromosomal context of the cardiac troponin I and slow skeletal troponin T genes reveals a region of densely packed differentially expressed genes, including new genes identified by automatic genome annotation. This information is discussed within the context of detailed analysis of the best-studied gene in this region, cardiac troponin I. In this way, we illustrate the uses to which a combination of conventional bench experiments and "in silico" analyses may be put in understanding the relationship between structure and function within the genome. (Mol Cell Biochem 263: 81-90, 2004).
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Registered trials
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