ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017
Pleomorphic adenomas of the salivary glands: retrospective multicentric study of 130 cases with emphasis on histopathological features.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Recurrent Pleomorphic Adenoma of the Palate: A Case Report.Clinics and practice · 2026Article
- Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20-Year Retrospective Analysis.Oral diseases · 2026Article
- Article
- Pleomorphic Adenoma with Epithelial Atypia, Apocrine Metaplasia, and/or In situ/Intracapsular Salivary Duct Carcinoma Are Indolent Lesions with Good Prognosis: A Proposal for Unified Nomenclature and Clinical Observation.Head and neck pathology · 2025Article
- The value of multi-phase CT based intratumor and peritumoral radiomics models for evaluating capsular characteristics of parotid pleomorphic adenoma.Frontiers in medicine · 2025Article
- Pleomorphic adenoma parotid surgery, how much margin we can reach to be safe?Dental research journal · 2025Article
- Retrospective Analysis of Histopathological Reports of Salivary Gland Pleomorphic Adenomas in Tanzania.The East African health research journal · 2024Article
- Correlation of Clinical and Histopathological Features of Salivary Pleomorphic Adenoma.Journal of dentistry (Shiraz, Iran) · 2023Article
- Diagnostic role of DOG-1, GFAP and B-catenin in Basal cell Adenoma and Cellular Pleomorphic Adenoma of the Salivary Gland.Head and neck pathology · 2023Article
- CT based intratumor and peritumoral radiomics for differentiating complete from incomplete capsular characteristics of parotid pleomorphic adenoma: a two-center study.Discover oncology · 2023Article
- Salivary gland tumors: A 13-year clinicopathologic retrospective study in a Brazilian northeast population.Journal of clinical and experimental dentistry · 2023Article
- MR Imaging Findings of Carcinoma Ex Pleomorphic Adenoma Related to Extracapsular Invasion and Prognosis.AJNR. American journal of neuroradiology · 2022Article
- Apparent Diffusion Coefficient (ADC) Histogram Analysis in Parotid Gland Tumors: Evaluating a Novel Approach for Differentiation between Benign and Malignant Parotid Lesions Based on Full Histogram Distributions.Diagnostics (Basel, Switzerland) · 2022Article
- Pleomorphic Adenoma of the Parotid Gland and the Parapharyngeal Space: Two Diametrically Opposing Surgical Philosophies for the Same Histopathologic Entity?Journal of clinical medicine · 2021Article
- [Diagnostic value of high-resolution ultrasonography in parotid space occupying lesions].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Challenges in Minor Salivary Gland Biopsies: A Practical Approach to Problematic Histologic Patterns.Head and neck pathology · 2019Review
- Pleomorphic adenoma of the mandibular salivary gland in a captive African pygmy hedgehog (Atelerix albiventris).The Journal of veterinary medical science · 2019Article
- Diagnostic value of single-source dual-energy spectral computed tomography in differentiating parotid gland tumors: initial results.Quantitative imaging in medicine and surgery · 2018Article
- Low Grade Carcinoma Ex-Pleomorphic Adenoma: Diagnosis and Diagnostic Challenges Caused by Fine Needle Aspiration: Report of Three Cases and Review of Literature.Head and neck pathology · 2018Review
- Cystic lesions of the parotid gland: radiologic-pathologic correlation according to the latest World Health Organization 2017 Classification of Head and Neck Tumours.Japanese journal of radiology · 2017Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pleomorphic adenoma (PA) is the most frequent benign epithelial lesion of salivary gland origin, showing great histopathological diversity. The aim of this study was to perform a retrospective analysis, with emphasis on histopathologic features of PA of salivary glands. Clinical and histopathologic characteristics of 130 cases of minor and major salivary glands PAs from three Brazilian reference centers were studied. Higher frequency of PAs was observed in female (55.4 %) subjects, with mean age of 49.7 years. The most common affected site was palate (64.5 %) for the PAs of minor salivary glands and parotid for cases affecting major glands (86.2 %). Microscopically, most cases were classified as classic PAs (50 %). Incomplete capsule was observed in 36.2 % of the cases, while 47.2 % showed capsular infiltration. Rounded (66.9 %), angular (49.2 %), oval (46.2 %) and plasmacytoid (39.2 %) cells were widely observed, as well as fibrous (73.8 %) and myxoid (69.2 %) stroma, squamous metaplasia (25.4 %) and cystic degeneration (43.1 %). Crystalloids (3.1 %), increased mitotic activity (5.4 %) and vascular invasion (2.3 %) were rarely observed. PAs arising in minor salivary glands were associated with incomplete capsules, spindle, oval, angular, plasmacytoid and pleomorphic cells, fibrous and hyaline stroma, cystic degeneration, squamous metaplasia and pleomorphism (p < 0.05). No association between capsular features and histological subtype was noted (p ≥ 0.05). These results confirm the findings of previous studies regarding major clinicopathological features of pleomorphic adenomas; and highlighted some important morphologic characteristics like the capsule, vascular invasion, pleomorphism and increased mitotic activity, which can reflect the biological behavior of these tumors.
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