ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Terpinen-4-ol, tyrosol, and β-lapachone as potential antifungals against dimorphic fungi.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Evaluation of the Quantitative and Structural Antimicrobial Activity of Thymol, Terpinen-4-ol, Citral, and E-2-Dodecenal, Antibiotic Molecules Derived from Essential Oils.Antibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial activity, ergosterol content and phytochemical screening of Rorippa Islandica (Oeder ex Murr.) and Carrichtera annua (L.).Scientific reports · 2025Article
- Uncovering the biosynthetic pathways of key flavor and color compounds in pomegranate using pathway-based metabolomics.RSC advances · 2025Article
- Activity of Common Thyme (Molecules (Basel, Switzerland) · 2024Article
- Antifungal activity of β-lapachone against a fluconazole-resistant Candida auris strain.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Total transcriptome analysis of Candida auris planktonic cells exposed to tyrosol.AMB Express · 2023Article
- Antifungal Compounds from Microbial Symbionts Associated with Aquatic Animals and Cellular Targets: A Review.Pathogens (Basel, Switzerland) · 2023Review
- Chemical Characterization ofMolecules (Basel, Switzerland) · 2023Article
- Essential Oils as a Good Weapon against Drug-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Essential Oils in Respiratory Mycosis: A Review.Molecules (Basel, Switzerland) · 2022Review
- Genome-Wide Identification of the Long Noncoding RNAs ofInsects · 2022Article
- In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone inMolecules (Basel, Switzerland) · 2021Article
- Antifungal Activity ofMolecules (Basel, Switzerland) · 2021Article
- Uncharted Source of Medicinal Products: The Case of theMedicines (Basel, Switzerland) · 2020Review
- Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review.Molecules (Basel, Switzerland) · 2019Review
- Antifungal activity of Gallesia integrifolia fruit essential oil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2018Article
- Metabolite analysis of endophytic fungi from cultivars of Zingiber officinale Rosc. identifies myriad of bioactive compounds including tyrosol.3 Biotech · 2017Article
- Secondary metabolites of endophytic Xylaria species with potential applications in medicine and agriculture.World journal of microbiology & biotechnology · 2017Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n=22) and Histoplasma capsulatum in both filamentous (n=40) and yeast phases (n=13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720μg/mL, 20-2860μg/mL, and 40-1420μg/mL, respectively for terpinen-4-ol; 250-4000μg/mL, 30-2000μg/mL, and 10-1000μg/mL, respectively, for tyrosol; and 0.48-7.8μg/mL, 0.25-16μg/mL, and 0.125-4μg/mL, respectively for β-lapachone. These compounds showed a decrease in MIC when the samples were subjected to osmotic stress, suggesting that the compounds acted on the fungal membrane. All the compounds were able to reduce the ergosterol content of the fungal strains. Finally, tyrosol was able to cause a leakage of intracellular molecules.
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