ArticleJournal of the American Academy of Dermatology2016
HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.
Article in Journal of the American Academy of Dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Antistreptococcal treatment of psoriasis: a systematic review.Archives of dermatological research · 2024Pooled it
- B Cells Can Trigger the T-Cell-Mediated Autoimmune Response Against Melanocytes in Psoriasis.Cells · 2025Article
- The impact of antibiotic therapy in psoriasis patients with active streptococcal infection: A prospective study.The Journal of dermatology · 2025Article
- Group AScience immunology · 2023Article
- Awareness and Perceptions of the Impact of Tonsillectomy on the Level of Immunity and Autoimmune Diseases among the Adult Population in Abha City, Kingdom of Saudi Arabia.Healthcare (Basel, Switzerland) · 2023Article
- Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection.Nature communications · 2022Article
- The role of HLA-Cw6 in psoriasis and psoriatic arthritis.Reumatologia · 2022Article
- Pediatric Psoriasis: From New Insights into Pathogenesis to Updates on Treatment.Biomedicines · 2021Review
- HLA-Cw1 and Psoriasis.American journal of clinical dermatology · 2021Review
- The Association Between Oral Health and Skin Disease.The Journal of clinical and aesthetic dermatology · 2020Article
- Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis.Archivum immunologiae et therapiae experimentalis · 2019Article
- Psoriasis Pathogenesis and Treatment.International journal of molecular sciences · 2019Review
- Unmet Needs in the Field of Psoriasis: Pathogenesis and Treatment.Clinical reviews in allergy & immunology · 2018Review
- The Psoriasis Risk AlleleInfection and immunity · 2018Article
- Psoriasis in Pediatric Age Group.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundCarriage of the HLA-Cw*0602 allele is associated with a particular set of clinical features and treatment responses in psoriasis. Tonsillectomy can improve psoriasis.
objectivesWe sought to evaluate whether HLA-Cw*0602 predicts a favorable outcome after tonsillectomy of patients with psoriasis.
methodsThis prospective case series followed up 28 tonsillectomized patients with plaque psoriasis for 24 months. The Psoriasis Area and Severity Index, Psoriasis Disability Index, and Psoriasis Life Stress Inventory were used for assessment. Tonsils were swabbed for bacteria and patients genotyped for HLA-Cw*0602.
resultsAfter tonsillectomy, HLA-Cw*0602 homozygotes showed significantly more improvement, compared with heterozygous and HLA-Cw*0602-negative patients. Thus, Psoriasis Area and Severity Index score was reduced by 82% in the homozygous patients compared with 42% and 31%, respectively (P < .001), Psoriasis Disability Index score improved by 87% compared with 38% and 41%, respectively (P < .001), and Psoriasis Life Stress Inventory score was 82% reduced compared with 60% and 54%, respectively (P < .001). The homozygotes more often had psoriasis onset associated with a throat infection (P = .007) and an increased frequency of streptococcal throat infections per lifetime (P = .038). LIMITATIONS: Few patients were included and some data were retrospective.
conclusionsHomozygous HLA-Cw*0602 carriage in plaque psoriasis may predict a favorable outcome after tonsillectomy.
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Registered trials
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