Evidence map›Paper›PMID 27520385›Full record

ArticleWorld journal of urology2017

Nephron sparing surgery for renal cell carcinoma up to 7 cm in the context of guideline development: a contribution of healthcare research.

Steffen Lebentrau, Sven Rauter, Daniel Baumunk, Frank Christoph, Frank König, Matthias May, Martin Schostak

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Article in World journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Steffen LebentrauDepartment of Urology and Pediatric Urology, Ruppin Clinics, Brandenburg Medical Center and School of Medicine, Fehrbelliner Straße 38, 16816, Neuruppin, Germany. s.lebentrau@ruppiner-kliniken.de.ORCID http://orcid.org/0000-0001-8782-3875
Sven RauterDepartment of Urology and Pediatric Urology, Ruppin Clinics, Brandenburg Medical Center and School of Medicine, Fehrbelliner Straße 38, 16816, Neuruppin, Germany.
Daniel BaumunkDepartment of Urology and Pediatric Urology, Magdeburg University Medical Center, Leipziger Str. 44, 39120, Magdeburg, Germany.
Frank ChristophDepartment of Urology and Pediatric Urology, Magdeburg University Medical Center, Leipziger Str. 44, 39120, Magdeburg, Germany.
Frank KönigDepartment of Urology and Pediatric Urology, Magdeburg University Medical Center, Leipziger Str. 44, 39120, Magdeburg, Germany.
Matthias MayDepartment of Urology, St. Elisabeth Hospital, St.-Elisabeth-Str. 23, 94315, Straubing, Germany.
Martin SchostakDepartment of Urology and Pediatric Urology, Magdeburg University Medical Center, Leipziger Str. 44, 39120, Magdeburg, Germany.
Medizinische Hochschule Brandenburg Theodor Fontane · DEUniversity Hospital Magdeburg · DEArbeitsgemeinschaft Urologische Onkologie · DEBarmherzige Brüder Klinikum St. Elisabeth in Straubing · DEFriedrich-Ebert-Stiftung e.V. · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIf technically feasible, organ-preservation is indicated for T1 renal cell carcinoma (RCC), since partial nephrectomy (PN) is equivalent to radical nephrectomy with regard to tumor-specific survival and probably achieves better overall survival. Treatment results of a training clinic were assessed with regard to guideline adherence and treatment quality.

methodsBased on 220 open interventions in the time periods 2006-2009 (TP1) and 2010-2013 (TP2), a retrospective single center examination was performed to determine the influence of patient-age, sex, BMI, ASA-score, preoperative eGFR, PADUA-score and surgeon's experience on PN-rate and trifecta-outcome (R0 resection, warm ischemia time ≤25 min, no intraoperative complications and no blood-transfusion and postoperative complications grade ≤1 Clavien and Dindo).

resultsPN-rate increased from 36.1 % in TP1 to 72.4 % in TP2. Despite significantly higher PADUA-scores in TP2 than in TP1 (p = 0.0038), the trifecta-rate did not differ significantly (TP1 65.7 %; TP2 70.8 %; p = 0.666). Only the PADUA-score exerted an independent influence on the endpoints "organ-preservation" and "trifecta-outcome".

conclusionsThis study again demonstrated that the PADUA-score is a robust predictor of technical feasibility and treatment outcome for open PN. Consistent implementation of guidelines for nephron sparing surgery in RCC ≤7 cm is possible even in the setting of a training clinic and need not be associated with compromised treatment quality despite the increasing level of difficulty. Depending on the author, there are various definitions of trifecta-outcome. A uniform trifecta-concept would be desirable.

Indexed as

NephronsAge FactorsBlood TransfusionBody Mass IndexCarcinoma, Renal CellFemaleGlomerular Filtration RateGuideline AdherenceHumansIntraoperative ComplicationsKidney NeoplasmsMaleMultivariate AnalysisNephrectomyOrgan Sparing TreatmentsPostoperative ComplicationsGuideline adherenceHealthcare researchPADUA scorePartial nephrectomyRenal cell carcinomaTrifecta

Identifiers

PMID27520385
OpenAlexW2510635324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.