ArticleEuropean radiology2017
Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Whole-body MRI for staging and follow-up of primary musculoskeletal tumours: a systematic review.The British journal of radiology · 2026Pooled it
- Multifocal Glucocorticoid-Associated Osteonecrosis: Clinical Characteristics and Systemic Molecular Features.Biomedicines · 2026Article
- [Bone infarctions-from pathophysiology to imaging].Radiologie (Heidelberg, Germany) · 2026Review
- Dual-energy CT in musculoskeletal imaging: technical considerations and clinical applications.La Radiologia medica · 2024Review
- Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: A potential cause of persistent tissue damage and follicle depletion.Journal of reproductive immunology · 2022Article
- Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe.Insights into imaging · 2021Review
- Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma.Diagnostics (Basel, Switzerland) · 2021Review
- Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis-a pilot study.Arthritis research & therapy · 2021Article
- Hip bone osteonecrosis with intraosseous pneumatosis after abdominal aortic aneurysm repair: a case of emphysematous osteomyelitis.BJR case reports · 2021Article
- Whole-body magnetic resonance imaging (WB-MRI) in oncology: an Italian survey.La Radiologia medica · 2021Article
- The "birth of death": MRI step-by-step reveals the early appearance of a bone marrow infarct.Acta radiologica open · 2019Article
- Clinical characteristics and role of whole-body bone scan in multifocal osteonecrosis.BMC musculoskeletal disorders · 2019Article
- Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now.European radiology · 2018Review
- Bone marrow oedema predicts bone collapse in paediatric and adolescent leukaemia patients with corticosteroid-induced osteonecrosis.European radiology · 2018Article
- Whole-body MRI in the early detection of multifocal osteonecrosis.The British journal of radiology · 2017Article
- Imaging features of solid renal masses.The British journal of radiology · 2017Review
- Whole-body magnetic resonance for staging and response assessment of lymphoma in a pregnant woman treated with antenatal chemotherapy.BJR case reports · 2017Article
- The Role of Whole-Body MRI in Patients with Lymphoma: A Narrative Review.Technology in cancer research & treatmentReview
- Caecal leiomyoma detected by whole-body MRI in a patient with Hodgkin lymphoma: first case report.Il Giornale di chirurgiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies.
methodsWe evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis.
resultsSix out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p < 0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, 48 % were detected in the knee; multifocal osteonecrosis were detected in six out of seven patients (86 %).
conclusionsThe development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows detecting earlier osteonecrotic lesions in patients treated with corticosteroids. KEY POINTS: • Osteonecrosis is a possible complication of patients with Lymphoma treated by chemotherapy. • Osteonecrosis is related to the corticosteroids included within the BEACOPP protocol. • WB-MRI allows detecting osteonecrotic lesions in patients treated with corticosteroids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.