ArticleBiological psychiatry2017
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
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Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 5 of them syntheses that pooled it.
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108citing papers in PubMed, 5 pooled it
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Who cites it
108 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Genetics of age-at-onset in major depression.Translational psychiatry · 2022Pooled it
- Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.Translational psychiatry · 2021Pooled it
- Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.Translational psychiatry · 2018Pooled it
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.Translational psychiatry · 2017Pooled it
- PMiScience · 2026Review
- Familial genetic risk for posttraumatic stress disorder: Associations with clinical features.Journal of traumatic stress · 2026Article
- Gender differences in clinical correlates of glucose disturbance in patients with first-episode and drug-naïve major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up.Molecular psychiatry · 2026Article
- Impact of Obesity, Menopause, and Depression in Women's Health: An Attempt to Decipher the Complex Relationship.Current medicinal chemistry · 2026Review
- Bidirectional associations of depression, anxiety, sleep disorders, and constipation: insights from Mendelian randomization.Archives of medical science : AMS · 2026Article
- Depression genetics through the lens of age at onset.Nature genetics · 2025Article
- Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.Nature genetics · 2025Article
- Genetic risk scores of psychiatric phenotypes are associated with depression risk in a prospective Dutch population-based cohort.Psychological medicine · 2025Article
- Genome-wide association study of adolescent-onset depression.medRxiv : the preprint server for health sciences · 2025Article
- Neural Activity Disparities in Deficiency and Excess Patterns of Depression: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2025Article
- Cumulative loneliness and memory function among U.S. older adults: the role of depressive symptoms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Peripheral MicroRNA Signatures in Adolescent Depression.Biological psychiatry global open science · 2025Article
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- The genetics of severe depression.Molecular psychiatry · 2025Review
48 more citing papers are in PubMed but not listed here.
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Authors and funding
77 authors.
Robert A PowerInstitute of Psychiatry, Psychology, and Neuroscience, King׳s College London, London.
Katherine E TanseyMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Henriette Nørmølle ButtenschønLundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Sarah Cohen-WoodsDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia.
Tim BigdeliDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Lynsey S HallDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Zoltán KutalikInstitute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
S Hong LeeQueensland Brain Institute, The University of Queensland, Brisbane, Queensland; School of Environmental and Rural Science, University of New England, Armidale, New South Wales, Australia.
Stephan RipkeStanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany.
Stacy SteinbergdeCODE Genetics, Reykjavik, Iceland.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Alexander ViktorinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Naomi R WrayQueensland Brain Institute, The University of Queensland, Brisbane, Queensland.
Volker AroltDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Bernard T BauneDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia.
Dorret I BoomsmaDepartment of Biological Psychology, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands.
Anders D BørglumLundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark; Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Enda M ByrneQueensland Brain Institute, The University of Queensland, Brisbane, Queensland.
Enrique CastelaoDepartment of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Nick CraddockMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Ian W CraigInstitute of Psychiatry, Psychology, and Neuroscience, King׳s College London, London.
Udo DannlowskiDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany; Department of Psychiatry, University of Marburg, Marburg, Germany.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Franziska DegenhardtInstitute of Human Genetics; Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Andreas J ForstnerInstitute of Human Genetics; Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Jakob GroveLundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark; Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
Steven P HamiltonDepartment of Psychiatry, Kaiser Permanente San Francisco Medical Center, San Francisco, California.
Caroline HaywardMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Andrew C HeathDepartment of Psychiatry, Washington University St. Louis, St. Louis, Missouri.
Lynne J HockingDivision of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald.
Jouke J HottengaDepartment of Biological Psychology, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands.
Stefan KloiberMax Planck Institute of Psychiatry, Munich, Germany.
Jesper KroghMental Health Center Copenhagen, Mental Health Services in Capital Region, University of Copenhagen, Copenhagen, Denmark.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Maren LangDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Douglas F LevinsonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Susanne LucaeMax Planck Institute of Psychiatry, Munich, Germany.
Donald J MacIntyreDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Pamela MaddenDepartment of Psychiatry, Washington University St. Louis, St. Louis, Missouri.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, United Kingdom.
Christel M MiddeldorpDepartment of Biological Psychology, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands.
Yuri MilaneschiDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Ole MorsLundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus University, Aarhus, Denmark; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Dale R NyholtInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Hogni OskarssonTherapeia, Reykjavik, Iceland.
Michael J OwenMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
Brenda W J H PenninxDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Michele L PergadiaCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida.
David J PorteousMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
James B PotashDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Martin PreisigDepartment of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Margarita RiveraInstitute of Psychiatry, Psychology, and Neuroscience, King׳s College London, London; CIBERSAM-Universidad de Granada e Instituto de Investigación Biosanitaria ibs, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Stanley I ShynDepartment of Psychiatry, Group Health, Seattle, Washington.
Engilbert SigurdssonUniversity of Iceland; Department of Psychiatry, Landspitali University Hospital, Reykjavik, Iceland.
Johannes H SmitDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Blair H SmithDivision of Population Health Sciences, University of Dundee, Dundee, United Kingdom.
Hreinn StefanssondeCODE Genetics, Reykjavik, Iceland.
Kari StefanssondeCODE Genetics, Reykjavik, Iceland.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Pippa ThomsonCentre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, United Kingdom; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Thorgeir E ThorgeirssondeCODE Genetics, Reykjavik, Iceland.
Sandra Van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Myrna M WeissmanCollege of Physicians and Surgeons and the Mailman School of Public Health, Columbia University and New York State Psychiatric Institute, New York, New York.
CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium
Gerome BreenInstitute of Psychiatry, Psychology, and Neuroscience, King׳s College London, London.
Cathryn M LewisInstitute of Psychiatry, Psychology, and Neuroscience, King׳s College London, London. Electronic address: cathryn.lewis@kcl.ac.uk.
Funding
AN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4MPharmacogenomics of Antidepressant ResponseR01MH072802 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAMILTON, STEVEN P. · 2005 to 2008
$4.6M2/2 A genome-wide association study to detect genetic variation for schizophreniaR01MH080403 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2008 to 2010
$4.5MMolecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3MGENETICS OF RECURRENT EARLY-ONSET DEPRESSIONR01MH061686 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI LEVINSON, DOUGLAS FREDERICK · 1999 to 2008
$3.8MGENETICS OF EARLY-ONSET MAJOR DEPRESSIONR01MH060912 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WEISSMAN, MYRNA M · 1999 to 2008
$3.3MMolecular Epidemiology of Alcoholism 2- Big SibshipsR01AA013320 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2003 to 2007
$3.1MInterstitial Cystitis in Swedish TwinsU01DK066134 · NIDDK · KAROLINSKA INSTITUTE · PI PEDERSEN, NANCY L · 2004 to 2008
$2.9MGENETICS OF EARLY ONSET DEPRESSIONR01MH059552 · NIMH · JOHNS HOPKINS UNIVERSITY · PI POTASH, JAMES B. · 1999 to 2008
$2.8MGenetic Epidemiology of Pathological GamblingR01MH066206 · NIMH · UNIVERSITY OF MISSOURI-COLUMBIA · PI SLUTSKE, WENDY S · 2003 to 2007
$2.5MMolecular Epidemiology of Alcoholism 1: Candidate GeneR01AA013326 · NIAAA · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MARTIN, NICHOLAS G · 2001 to 2005
$2.1MChief Scientist Office CZD/16/6/4Medical Research Council G0000647Medical Research Council G0701420Medical Research Council MC_PC_U127561128Medical Research Council MR/K026992/1NCRR NIH HHS U54 RR020278NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIDA NIH HHS K08 DA019951NIDA NIH HHS R01 DA012854NIDA NIH HHS R56 DA012854NIDDK NIH HHS U01 DK066134NIMH NIH HHS N01 MH090003NIMH NIH HHS R01 MH059541NIMH NIH HHS R01 MH059542NIMH NIH HHS R01 MH059552NIMH NIH HHS R01 MH060912NIMH NIH HHS R01 MH061686NIMH NIH HHS R01 MH066206NIMH NIH HHS R01 MH072802NIMH NIH HHS R01 MH075131NIMH NIH HHS R01 MH080403NIMH NIH HHS R01 MH081802NIMH NIH HHS U01 MH085520Wellcome Trust
Abstract
backgroundMajor depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset.
methodsDiscovery case-control genome-wide association studies were performed where cases were stratified using increasing/decreasing age-at-onset cutoffs; significant single nucleotide polymorphisms were tested in nine independent replication samples, giving a total sample of 22,158 cases and 133,749 control subjects for subsetting. Polygenic score analysis was used to examine whether differences in shared genetic risk exists between earlier and adult-onset MDD with commonly comorbid disorders of schizophrenia, bipolar disorder, Alzheimer's disease, and coronary artery disease.
resultsWe identified one replicated genome-wide significant locus associated with adult-onset (>27 years) MDD (rs7647854, odds ratio: 1.16, 95% confidence interval: 1.11-1.21, p = 5.2 × 10
conclusionsWe demonstrate that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size. Furthermore, our results suggest that the genetic susceptibility to MDD differs between adult- and earlier-onset MDD, with earlier-onset cases having a greater genetic overlap with schizophrenia and bipolar disorder.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAdultAge of OnsetBipolar DisorderCase-Control StudiesFemaleHumansMajor Depressive DisorderMaleMultifactorial InheritancePhenotypePolymorphism, Single NucleotideRisk FactorsSchizophreniaYoung AdultAge at onsetGWASHeterogeneityMajor depressive disorderPolygenic scoringStratification
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