ArticleGenetics2016
Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Breed-specific immune regulation under endemic exposure to Leishmania infantum and other vector-borne pathogens in a native Mediterranean canine population.Parasites & vectors · 2026Article
- Purebred dogs show higher levels of genomic damage compared to mixed breed dogs.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- An In-Depth Look at Fonni's Dog Behavior under Different Outdoor Conditions.Animals : an open access journal from MDPI · 2024Article
- The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds.Animals : an open access journal from MDPI · 2023Article
- Identification of Genomic Signatures in Bullmastiff Dogs Using Composite Selection Signals Analysis of 23 Purebred Clades.Animals : an open access journal from MDPI · 2023Article
- Genomic Analysis of the Endangered Fonni's Dog Breed: A Comparison of Genomic and Phenotypic Evaluation Scores.Animals : an open access journal from MDPI · 2023Article
- A Preliminary Study on the Interplay between the Serum Levels of Neurotransmitters and Thyroid Hormones for the Evaluation of the Behavioral Phenotype of Dogs.Animals : an open access journal from MDPI · 2023Article
- Extender Supplementation with Glutathione (GSH) and Taurine ImprovesVeterinary medicine international · 2023Article
- Selection Signatures in Italian Livestock Guardian and Herding Shepherd Dogs.Veterinary sciences · 2022Article
- Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America.PLoS genetics · 2022Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- The effect of inbreeding, body size and morphology on health in dog breeds.Canine medicine and genetics · 2021Article
- Seroprevalence and risk factors associated with exposure to Leishmania infantum in dogs, in an endemic Mediterranean region.PloS one · 2021Article
- Genomic Characterization of the Istrian Shorthaired Hound.Animals : an open access journal from MDPI · 2020Article
- Genetic analysis of the modern Australian labradoodle dog breed reveals an excess of the poodle genome.PLoS genetics · 2020Article
- The German Shorthair Pointer Dog Breed (Animals : an open access journal from MDPI · 2020Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
- Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health.National science review · 2019Article
- Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology.Nature communications · 2019Article
- Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging.Frontiers in genetics · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The island inhabitants of Sardinia have long been a focus for studies of complex human traits due to their unique ancestral background and population isolation reflecting geographic and cultural restriction. Population isolates share decreased genomic diversity, increased linkage disequilibrium, and increased inbreeding coefficients. In many regions, dogs and humans have been exposed to the same natural and artificial forces of environment, growth, and migration. Distinct dog breeds have arisen through human-driven selection of characteristics to meet an ideal standard of appearance and function. The Fonni's Dog, an endemic dog population on Sardinia, has not been subjected to an intensive system of artificial selection, but rather has developed alongside the human population of Sardinia, influenced by geographic isolation and unregulated selection based on its environmental adaptation and aptitude for owner-desired behaviors. Through analysis of 28 dog breeds, represented with whole-genome sequences from 13 dogs and ∼170,000 genome-wide single nucleotide variants from 155 dogs, we have produced a genomic illustration of the Fonni's Dog. Genomic patterns confirm within-breed similarity, while population and demographic analyses provide spatial identity of Fonni's Dog to other Mediterranean breeds. Investigation of admixture and fixation indices reveals insights into the involvement of Fonni's Dogs in breed development throughout the Mediterranean. We describe how characteristics of population isolates are reflected in dog breeds that have undergone artificial selection, and are mirrored in the Fonni's Dog through traditional isolating factors that affect human populations. Lastly, we show that the genetic history of Fonni's Dog parallels demographic events in local human populations.
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