Evidence map›Paper›PMID 27519585›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2016

Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer.

Daniel L P Holyoake, Maxwell Robinson, Derek Grose, David McIntosh, David Sebag-Montefiore, Ganesh Radhakrishna, Neel Patel, Mike Partridge, Somnath Mukherjee, Maria A Hawkins

Open access · hybridAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Daily breathing inconsistency in pancreas SBRT: a 4DCT study.Journal of gastrointestinal oncology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Daniel L P HolyoakeCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK; The Churchill Hospital, Oxford, UK.
Maxwell RobinsonCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK; The Churchill Hospital, Oxford, UK.
Derek GroseThe Beatson West of Scotland Cancer Centre, Glasgow, UK.
David McIntoshThe Beatson West of Scotland Cancer Centre, Glasgow, UK.
David Sebag-MontefioreUniversity of Leeds, CRUK Leeds Centre, UK; Leeds Cancer Centre, St James's University Hospital, Leeds, UK.
Ganesh RadhakrishnaLeeds Cancer Centre, St James's University Hospital, Leeds, UK.
Neel PatelThe Churchill Hospital, Oxford, UK.
Mike PartridgeCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK.
Somnath MukherjeeCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK; The Churchill Hospital, Oxford, UK.
Maria A HawkinsCRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK; The Churchill Hospital, Oxford, UK. Electronic address: maria.hawkins@oncology.ox.ac.uk.
University of Oxford · GBBeatson West of Scotland Cancer Centre · GBCRUK/MRC Oxford Institute for Radiation Oncology · GBChurchill Hospital · GBSt James's University Hospital · GBUniversity of Leeds · GB

Funding

Cancer Research UK 16049Cancer Research UK 18787Medical Research Council MC_PC_12001/2
6 · The paper itself

Abstract

background and purposeMargin-directed neoadjuvant radiotherapy for borderline-resectable pancreatic cancer (BRPC) aims to facilitate clear surgical margins. A systematic method was developed for definition of a boost target volume prior to a formal phase-I study. MATERIAL AND

methodsReference structures were defined by two oncologists and one radiologist, target structures were submitted by eight oncologist investigators and compared using conformity indices. Resultant risk of duodenal bleed (NTCP) was modelled.

resultsFor GTV, reference volume was 2.1cm

conclusionsBetter conformity with reference was shown for boost volume compared with GTV. Investigator GTV volumes were larger than reference, had higher DI scores and modelled toxicity risk. A consistent method of target structure definition for margin-directed pancreatic radiotherapy is demonstrated.

Indexed as

HumansNeoadjuvant TherapyPancreatic NeoplasmsPositron-Emission TomographyRadiosurgeryRadiotherapy Planning, Computer-AssistedReproducibility of ResultsTomography, X-Ray ComputedBorderline-resectablePancreatic cancerRadiation therapy quality assuranceSBRTTarget volume definition

Identifiers

PMID27519585
PMCPMC5100802
OpenAlexW2502594064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.