Evidence map›Paper›PMID 27519415›Full record

ArticleThe Journal of biological chemistry2016

A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery.

Avery G Frey, Daniel J Palenchar, Justin D Wildemann, Caroline C Philpott

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Cellular Iron Homeostasis.Advances in experimental medicine and biology · 2025
    Review
  6. Mitochondria function in cytoplasmic FeS protein biogenesis.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  7. Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Integrative analysis of the role ofFrontiers in genetics · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Sulfur Administration in Fe-S Cluster Homeostasis.Antioxidants (Basel, Switzerland) · 2021
    Review
  19. The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Avery G FreyFrom the Genetics and Metabolism Section, Liver Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and.
Daniel J PalencharFrom the Genetics and Metabolism Section, Liver Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and.
Justin D Wildemannthe College of Medicine, Ohio State University, Columbus, Ohio 43210.
Caroline C PhilpottFrom the Genetics and Metabolism Section, Liver Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and Carolinep@mail.nih.gov.
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · USThe Ohio State University · US

Funding

Identification of human genes of iron homeostasisZIADK054510 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PHILPOTT, CAROLINE · 2009 to 2025
$27.6M
6 · The paper itself

Abstract

Cells contain hundreds of proteins that require iron cofactors for activity. Iron cofactors are synthesized in the cell, but the pathways involved in distributing heme, iron-sulfur clusters, and ferrous/ferric ions to apoproteins remain incompletely defined. In particular, cytosolic monothiol glutaredoxins and BolA-like proteins have been identified as [2Fe-2S]-coordinating complexes

Indexed as

Carrier ProteinsCells, CulturedCytosolHEK293 CellsHumansIron-Sulfur ProteinsProteinsBOLA2 protein, humanCarrier ProteinsGLRX3 protein, humanIron-Sulfur ProteinsProteinsbiotinBolA2Ciapin1Glrx3ironiron-sulfur proteinmetal homeostasismetal ion-protein interactionmetalloproteinNdor1

Identifiers

PMID27519415
PMCPMC5077177
OpenAlexW2509143425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.