SynthesisPloS one2016
Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Implementation and Evaluation of Environment-Derived Dust-Based Environmental Health Monitoring in an Open-Top Housing Laboratory Animal Facility.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Twenty years of health monitoring in a conventional neuroscience animal facility: challenges, strategies, and 3Rs-oriented approaches to animal welfare, personnel health, and research integrity.Frontiers in physiology · 2026Article
- Institutional Cost Savings and Improved Pathogen Detection by Replacing Sentinel Mice with Environmental Soiled Bedding Health Monitoring Methods.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Improved Detection of Murine Pathogens Using Sentinel-Free Media Compared to Live Animal Sampling.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Detection and Remediation of Pneumocystis murina Infections by Environmental Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A survey on the implementation of environmental health monitoring in mouse facilities in German-speaking countries.PloS one · 2025Article
- Pathogen Prevalence Estimates and Diagnostic Methodology Trends in Laboratory Mice and Rats from 2003 to 2020.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- A Cross-sectional Survey on Rodent Environmental Health Monitoring Practices: Benchmarking, Associations, and Barriers.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Microbiota and environmental health monitoring of mouse colonies by metagenomic shotgun sequencing.World journal of microbiology & biotechnology · 2022Article
- Using Filter Media and Soiled Bedding in Disposable Individually Ventilated Cages as a Refinement to Specific Pathogen-free Mouse Health Monitoring Programs.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Using Sterile Flocked Swabs as an Alternative Method for Rodent Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Detection and Transmission ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Basic reproduction numbers of three strains of mouse hepatitis viruses in mice.Microbiology and immunology · 2022Article
- Exposure to soiled bedding reduces abnormal repetitive behaviors in mice.Frontiers in behavioral neuroscience · 2022Article
- SDAV, the Rat Coronavirus-How Much Do We Know about It in the Light of Potential Zoonoses.Viruses · 2021Review
- A comprehensive approach for microbiota and health monitoring in mouse colonies using metagenomic shotgun sequencing.Animal microbiome · 2021Article
- Health Monitoring of Laboratory Rodent Colonies-Talking about (R)evolution.Animals : an open access journal from MDPI · 2021Review
- Simultaneous serodetection of major rat infectious pathogens by a multiplex immunochromatographic assay.Experimental animals · 2021Article
- PCR Testing of Media Placed in Soiled Bedding as a Method for Mouse Colony Health Surveillance.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review was conducted to gain insight into the efficacy of transmission of infectious agents to colony sentinels by soiled bedding transfer based on publications studying this subject in mice and rats. This information is essential to establish recommendations for the design of health monitoring programs which use sentinels to determine the microbiological status of laboratory animal colonies.
resultsFifteen original articles retrieved from PubMed, Embase, and CAB abstracts met the inclusion criteria. The design of the studies varied substantially per infectious agent with regard to dose of soiled bedding, exposure time, and sentinel strains used.
conclusionWith our conservative criteria for effectiveness, soiled bedding transfer appeared to be effective for MHV, MPV, TMEV, Helicobacter spp., and fur mite infections and ineffective for Sendai virus. For other infectious agents, such as MNV, EDIM, MVM, SDAV, Clostridium piliforme, and pinworms, too few data were available to be able to draw robust conclusions on the efficacy of soiled bedding transfer. RECOMMENDATION: The identified evidence only pertains to a portion of the infectious organisms included in the FELASA 2014 guidelines. As many animal facilities design their health monitoring program according to these recommendations, additional studies are warranted to draw comprehensive conclusions on the effective transmission of the infectious agents listed in these guidelines by soiled bedding transfer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.