ArticlePsychopharmacology2016
Reversal learning and experimenter-administered chronic intermittent ethanol exposure in male rats.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Alcohol or Stress Exposure During Late Adolescence Impairs Risk Assessment Later in Life, Disrupting the Ethological Structure of Behavior in Mice.Alcohol, clinical & experimental research · 2026Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- The null effect of stress on cognitive flexibility in individuals with and without alcohol use disorder.Drug and alcohol dependence · 2025Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.Molecular psychiatry · 2023Article
- The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years.Frontiers in neuroscience · 2022Review
- Alcohol-Drinking Under Limited-Access Procedures During Mature Adulthood Accelerates the Onset of Cognitive Impairment in Mice.Frontiers in behavioral neuroscience · 2022Article
- Adolescent Ethanol Exposure Alters Cholinergic Function and Apical Dendritic Branching Within the Orbital Frontal Cortex.Neuroscience · 2021Article
- Translational opportunities in animal and human models to study alcohol use disorder.Translational psychiatry · 2021Review
- Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking.Addiction biology · 2021Article
- Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry.International review of neurobiology · 2021Review
- Chronic Ethanol Exposure during Adolescence Increases Voluntary Ethanol Consumption in Adulthood in Female Sprague Dawley Rats.Brain sciences · 2020Article
- Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?Alcoholism, clinical and experimental research · 2020Review
- Dose-dependent effects of alcohol injections on omission-contingency learning have an inverted-U pattern.Behavioural brain research · 2020Article
- Aberrations in Incentive Learning and Responding to Heroin in Male Rats After Adolescent or Adult Chronic Binge-Like Alcohol Exposure.Alcoholism, clinical and experimental research · 2020Article
- Article
- Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model.Scientific reports · 2019Article
- Persistent Alterations of Accumbal Cholinergic Interneurons and Cognitive Dysfunction after Adolescent Intermittent Ethanol Exposure.Neuroscience · 2019Article
- Operant over-responding is more sensitive than reversal learning for revealing behavioral changes after withdrawal from alcohol consumption.Physiology & behavior · 2018Article
- Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure.Alcoholism, clinical and experimental research · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleChronic alcohol exposure is associated with impaired decision making skills, cognitive deficits, and poor performance on tasks requiring behavioral flexibility. Although oral routes of alcohol administration are commonly used to examine effects of alcohol on various behaviors in rodents, only a few investigations have used intragastric exposures to evaluate ethanol's effects on behavioral flexibility in the adult rat.
objectivesThe aim of the current series of experiments was to determine if behavioral flexibility impairments would be demonstrated across a variety of procedural factors, including route of administration [intraperitoneal injection (i.p.), intragastric gavage (i.g.)], ethanol dose (3-5 g/kg), number of daily exposures (once/day, twice/day), duration of exposure (2-6 weeks), or length of abstinence (5-7 days).
methodsAdult male Sprague-Dawley rats were exposed to chronic intermittent ethanol (CIE) or vehicle and evaluated for behavioral intoxication, blood ethanol concentrations (BEC), and performance on a reversal learning odor discrimination task.
resultsWhile all rats displayed behavioral intoxication and elevated BECs, CIE i.p. rats had prolonged elevation in BECs and made the most errors during the reversal learning task. Unexpectedly, CIE i.g. exposures failed to produce deficits during reversal learning tasks regardless of ethanol dose, frequency/duration of exposure, or length of abstinence.
conclusionsBehavioral flexibility deficits resulting from CIE i.p. exposures may be due to the severity and chronicity of alcohol intoxication. Elucidating the impact of ethanol on behavioral flexibility is critical for developing a better understanding of the behavioral consequences of chronic alcohol exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.