ArticleCell death and differentiation2016
The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.
Article in Cell death and differentiation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae.Scientific reports · 2025Article
- Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification.BMC genomic data · 2024Article
- Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies.Frontiers in endocrinology · 2022Review
- Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.Cell death and differentiation · 2021Article
- OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.Nature communications · 2020Article
- Analysis of Drosophila melanogaster testis transcriptome.BMC genomics · 2018Article
- Proapoptotic function of deubiquitinaseOncotarget · 2017Article
- Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease.Cell death and differentiation · 2017Review
- More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Cell death and differentiation · 2017Review
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7 authors.
Funding
Abstract
De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cell survival, we identified the Drosophila ovarian tumour-type DUB DUBA (CG6091). DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye. Searching also for non-apoptotic functions of DUBA, we found that Duba-null mutants are male sterile and display defects in spermatid individualisation, a process that depends on non-apoptotic caspase activity. Spermatids of DUBA-deficient flies showed reduced caspase activity and lack critical structures of the individualisation process. Biochemical characterisation revealed an obligate activation step of DUBA by phosphorylation. With genetic rescue experiments we demonstrate that DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis. Our results demonstrate for the first time the importance of de-ubiquitylation for fly spermatogenesis.
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