Evidence map›Paper›PMID 27518307›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society1997

CAND3: A ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 1lq23.1.

X Chen, L Yang, N Udar, T Liang, N Uhrhammer, S Xu, J O Bay, Z Wang, S Dandakar, S Chiplunkar and 5 more

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Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

X ChenDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
L YangDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
N UdarDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
T LiangDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
N UhrhammerDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
S XuDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
J O BayDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
Z WangDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
S DandakarDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
S ChiplunkarDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
I KlisakDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
M TelatarDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
H YangDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.
P ConcannonVirginia Mason Research Center and the Department of Immunology, University of Washington School of Medicine, 98101, Seattle, Washington, USA.
R A GattiDepartment of Pathology, UCLA School of Medicine, 90095 1732, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a magnetic beads-mediated cDNA selection procedure and a fetal brain expression library, we identified a transcriptional unit within a cosmid positive for the marker D11S384. Pursuit of its full-length cDNA led to the cloning of the third candidate gene (CAND3) we studied in our quest for the ataxiatelangiectasia (A-T) gene, ATM. CAND3 spans ~140 kb of genomic DNA and is located immediately centrimeric to ATM, with 544 bp of DNA separating the two genes. CAND3 encodes two ubiquitously expressed transcripts of ~5.8 kb and ~4.6 kb that are divergently transcribed from a promoter region common to ATM. Nucleotide sequence was determined for one of its alternately spliced transcripts. The predicted protein has 1175 amino acids and is novel in sequence, with only weak homologies to transcriptional factors, nucleoporin protein, and protein kinases, including members of the phosphatidylinositol 3-kinase (PI-3 kinase) family. Although neither homology to ATM nor any mutation of CAND3 in A-T patients has been found, the head-to-head arrangement of CAND3 and ATM, with expression of both housekeeping genes from a common stretch of 544 bp intergenic DNA, suggests a bi-directional promoter possibly for co-regulation of biologically related functions. YACs, BACs, cosmids, and STSs are defined to aid in the further study of this gene.

Identifiers

PMID27518307

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