ArticlePloS one2016
Genetic and Sex-Specific Transgenerational Effects of a High Fat Diet in Drosophila melanogaster.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Plant-derived soft electrophiles upregulate pro-resolving oxylipins in a paraquat-inducedbioRxiv : the preprint server for biology · 2026Article
- Influence of developmental diet on adult energy reserves in Drosophila.BMC biology · 2025Article
- Transgenerational pathogen effects: Maternal pathogen exposure reduces offspring fitness.Ecology · 2025Article
- Increased expression of the small lysosomal gene SVIP in the Drosophila gut suppresses pathophysiological features associated with a high-fat diet.Biology open · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Impact of Parental Time-Restricted Feeding on Offspring Metabolic Phenotypic Traits.International journal of biological sciences · 2025Article
- Sex-specific transgenerational effects of diet on offspring life history and physiology.Proceedings. Biological sciences · 2024Article
- Reference genes to study the sex-biased expression of genes regulating Drosophila metabolism.Scientific reports · 2024Article
- Paternal Western diet causes transgenerational increase in food consumption in Drosophila with parallel alterations in the offspring brain proteome and microRNAs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Parental ecological history can differentially modulate parental age effects on offspring physiological traits inCurrent zoology · 2022Article
- Sexual Dimorphism in Metabolic Responses to Western Diet inBiomolecules · 2021Article
- Repeated ethanol intoxications of Drosophila melanogaster adults increases the resistance to ethanol of their progeny.Alcoholism, clinical and experimental research · 2021Article
- Influence of Lab Adapted Natural Diet and Microbiota on Life History and Metabolic Phenotype ofMicroorganisms · 2020Article
- Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function.Addiction biology · 2020Article
- Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice.Environmental health perspectives · 2020Article
- Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Ancestral and offspring nutrition interact to affect life-history traits in Drosophila melanogaster.Proceedings. Biological sciences · 2019Article
- Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer.Scientific reports · 2018Article
- Environmentally induced epigenetic transgenerational inheritance of disease.Environmental epigenetics · 2018Review
- Parental obesity leads to metabolic changes in the F2 generation inMolecular metabolism · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
An organism's phenotype is the product of its environment and genotype, but an ancestor's environment can also be a contributing factor. The recent increase in caloric intake and decrease in physical activity of developed nations' populations is contributing to deteriorating health and making the study of the longer term impacts of a changing lifestyle a priority. The dietary habits of ancestors have been shown to affect phenotype in several organisms, including humans, mice, and the fruit fly. Whether the ancestral dietary effect is purely environmental or if there is a genetic interaction with the environment passed down for multiple generations, has not been determined previously. Here we used the fruit fly, Drosophila melanogaster, to investigate the genetic, sex-specific, and environmental effects of a high fat diet for three generations' on pupal body weights across ten genotypes. We also tested for genotype-specific transgenerational effects on metabolic pools and egg size across three genotypes. We showed that there were substantial differences in transgenerational responses to ancestral diet between genotypes and sexes through both first and second descendant generations. Additionally, there were differences in phenotypes between maternally and paternally inherited dietary effects. We also found a treated organism's reaction to a high fat diet was not a consistent predictor of its untreated descendants' phenotype. The implication of these results is that, given our interest in understanding and preventing metabolic diseases like obesity, we need to consider the contribution of ancestral environmental experiences. However, we need to be cautious when drawing population-level generalization from small studies because transgenerational effects are likely to exhibit substantial sex and genotype specificity.
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